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A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathw...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593924/ https://www.ncbi.nlm.nih.gov/pubmed/31234647 http://dx.doi.org/10.1177/2324709619858643 |
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author | Umyarova, Elvira Adapa, Sreedhar Naramala, Srikanth Gayam, Vijay Aeddula, Narothama Reddy Konala, Venu Madhav |
author_facet | Umyarova, Elvira Adapa, Sreedhar Naramala, Srikanth Gayam, Vijay Aeddula, Narothama Reddy Konala, Venu Madhav |
author_sort | Umyarova, Elvira |
collection | PubMed |
description | Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathways and abnormal proliferation of MCL cells. Patients can present with an indolent course or a fulminant disease with short overall survival. The disease frequently involves extranodal organs, but rarely manifests with neurological symptoms. We report a rare case of aberrant CD5-negative MCL presenting with aseptic meningitis. |
format | Online Article Text |
id | pubmed-6593924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-65939242019-07-01 A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis Umyarova, Elvira Adapa, Sreedhar Naramala, Srikanth Gayam, Vijay Aeddula, Narothama Reddy Konala, Venu Madhav J Investig Med High Impact Case Rep Case Report Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathways and abnormal proliferation of MCL cells. Patients can present with an indolent course or a fulminant disease with short overall survival. The disease frequently involves extranodal organs, but rarely manifests with neurological symptoms. We report a rare case of aberrant CD5-negative MCL presenting with aseptic meningitis. SAGE Publications 2019-06-24 /pmc/articles/PMC6593924/ /pubmed/31234647 http://dx.doi.org/10.1177/2324709619858643 Text en © 2019 American Federation for Medical Research http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Umyarova, Elvira Adapa, Sreedhar Naramala, Srikanth Gayam, Vijay Aeddula, Narothama Reddy Konala, Venu Madhav A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis |
title | A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis |
title_full | A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis |
title_fullStr | A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis |
title_full_unstemmed | A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis |
title_short | A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis |
title_sort | rare manifestation of a rare disease: mantle cell lymphoma presenting with aseptic meningitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593924/ https://www.ncbi.nlm.nih.gov/pubmed/31234647 http://dx.doi.org/10.1177/2324709619858643 |
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