A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis

Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathw...

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Autores principales: Umyarova, Elvira, Adapa, Sreedhar, Naramala, Srikanth, Gayam, Vijay, Aeddula, Narothama Reddy, Konala, Venu Madhav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593924/
https://www.ncbi.nlm.nih.gov/pubmed/31234647
http://dx.doi.org/10.1177/2324709619858643
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author Umyarova, Elvira
Adapa, Sreedhar
Naramala, Srikanth
Gayam, Vijay
Aeddula, Narothama Reddy
Konala, Venu Madhav
author_facet Umyarova, Elvira
Adapa, Sreedhar
Naramala, Srikanth
Gayam, Vijay
Aeddula, Narothama Reddy
Konala, Venu Madhav
author_sort Umyarova, Elvira
collection PubMed
description Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathways and abnormal proliferation of MCL cells. Patients can present with an indolent course or a fulminant disease with short overall survival. The disease frequently involves extranodal organs, but rarely manifests with neurological symptoms. We report a rare case of aberrant CD5-negative MCL presenting with aseptic meningitis.
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spelling pubmed-65939242019-07-01 A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis Umyarova, Elvira Adapa, Sreedhar Naramala, Srikanth Gayam, Vijay Aeddula, Narothama Reddy Konala, Venu Madhav J Investig Med High Impact Case Rep Case Report Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathways and abnormal proliferation of MCL cells. Patients can present with an indolent course or a fulminant disease with short overall survival. The disease frequently involves extranodal organs, but rarely manifests with neurological symptoms. We report a rare case of aberrant CD5-negative MCL presenting with aseptic meningitis. SAGE Publications 2019-06-24 /pmc/articles/PMC6593924/ /pubmed/31234647 http://dx.doi.org/10.1177/2324709619858643 Text en © 2019 American Federation for Medical Research http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Umyarova, Elvira
Adapa, Sreedhar
Naramala, Srikanth
Gayam, Vijay
Aeddula, Narothama Reddy
Konala, Venu Madhav
A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
title A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
title_full A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
title_fullStr A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
title_full_unstemmed A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
title_short A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis
title_sort rare manifestation of a rare disease: mantle cell lymphoma presenting with aseptic meningitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593924/
https://www.ncbi.nlm.nih.gov/pubmed/31234647
http://dx.doi.org/10.1177/2324709619858643
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