Tumefactive Demyelination versus Primary Central Nervous System Lymphoma on (18)F-Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Twist in the Tale

Demyelinating lesions of the central nervous system (CNS) are classically known to be hypometabolic on (18)F-Flurodeoxyglucose Positron Emission Tomography ((18)F-FDG PET). However, demyelinating lesions may show increased tracer uptake on (18)F-FDG PET and can radiologically mimic neoplasm. Delayed...

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Detalles Bibliográficos
Autores principales: Biswas, Shamick, Nagaraj, Chandana, Mangalore, Sandhya, Gupta, Arun Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593932/
https://www.ncbi.nlm.nih.gov/pubmed/31293309
http://dx.doi.org/10.4103/ijnm.IJNM_31_19
Descripción
Sumario:Demyelinating lesions of the central nervous system (CNS) are classically known to be hypometabolic on (18)F-Flurodeoxyglucose Positron Emission Tomography ((18)F-FDG PET). However, demyelinating lesions may show increased tracer uptake on (18)F-FDG PET and can radiologically mimic neoplasm. Delayed tracer uptake on FDG PET is one of the diagnostic hallmarks of primary CNS lymphoma (PCNSL). Here, we present two cases in which the brain lesions showed increased FDG uptake on delayed integrated PET Magnetic Resonance Imaging (MRI), which were pathologically proven as CNS demyelination. Such demyelinating lesions may also act as “sentinel lesions” and potential harbinger of PCNSL on follow-up.

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