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Tumefactive Demyelination versus Primary Central Nervous System Lymphoma on (18)F-Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Twist in the Tale

Demyelinating lesions of the central nervous system (CNS) are classically known to be hypometabolic on (18)F-Flurodeoxyglucose Positron Emission Tomography ((18)F-FDG PET). However, demyelinating lesions may show increased tracer uptake on (18)F-FDG PET and can radiologically mimic neoplasm. Delayed...

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Autores principales: Biswas, Shamick, Nagaraj, Chandana, Mangalore, Sandhya, Gupta, Arun Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593932/
https://www.ncbi.nlm.nih.gov/pubmed/31293309
http://dx.doi.org/10.4103/ijnm.IJNM_31_19
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author Biswas, Shamick
Nagaraj, Chandana
Mangalore, Sandhya
Gupta, Arun Kumar
author_facet Biswas, Shamick
Nagaraj, Chandana
Mangalore, Sandhya
Gupta, Arun Kumar
author_sort Biswas, Shamick
collection PubMed
description Demyelinating lesions of the central nervous system (CNS) are classically known to be hypometabolic on (18)F-Flurodeoxyglucose Positron Emission Tomography ((18)F-FDG PET). However, demyelinating lesions may show increased tracer uptake on (18)F-FDG PET and can radiologically mimic neoplasm. Delayed tracer uptake on FDG PET is one of the diagnostic hallmarks of primary CNS lymphoma (PCNSL). Here, we present two cases in which the brain lesions showed increased FDG uptake on delayed integrated PET Magnetic Resonance Imaging (MRI), which were pathologically proven as CNS demyelination. Such demyelinating lesions may also act as “sentinel lesions” and potential harbinger of PCNSL on follow-up.
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spelling pubmed-65939322019-07-11 Tumefactive Demyelination versus Primary Central Nervous System Lymphoma on (18)F-Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Twist in the Tale Biswas, Shamick Nagaraj, Chandana Mangalore, Sandhya Gupta, Arun Kumar Indian J Nucl Med Interesting Image Demyelinating lesions of the central nervous system (CNS) are classically known to be hypometabolic on (18)F-Flurodeoxyglucose Positron Emission Tomography ((18)F-FDG PET). However, demyelinating lesions may show increased tracer uptake on (18)F-FDG PET and can radiologically mimic neoplasm. Delayed tracer uptake on FDG PET is one of the diagnostic hallmarks of primary CNS lymphoma (PCNSL). Here, we present two cases in which the brain lesions showed increased FDG uptake on delayed integrated PET Magnetic Resonance Imaging (MRI), which were pathologically proven as CNS demyelination. Such demyelinating lesions may also act as “sentinel lesions” and potential harbinger of PCNSL on follow-up. Medknow Publications & Media Pvt Ltd 2019 /pmc/articles/PMC6593932/ /pubmed/31293309 http://dx.doi.org/10.4103/ijnm.IJNM_31_19 Text en Copyright: © 2019 Indian Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Interesting Image
Biswas, Shamick
Nagaraj, Chandana
Mangalore, Sandhya
Gupta, Arun Kumar
Tumefactive Demyelination versus Primary Central Nervous System Lymphoma on (18)F-Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Twist in the Tale
title Tumefactive Demyelination versus Primary Central Nervous System Lymphoma on (18)F-Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Twist in the Tale
title_full Tumefactive Demyelination versus Primary Central Nervous System Lymphoma on (18)F-Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Twist in the Tale
title_fullStr Tumefactive Demyelination versus Primary Central Nervous System Lymphoma on (18)F-Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Twist in the Tale
title_full_unstemmed Tumefactive Demyelination versus Primary Central Nervous System Lymphoma on (18)F-Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Twist in the Tale
title_short Tumefactive Demyelination versus Primary Central Nervous System Lymphoma on (18)F-Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Twist in the Tale
title_sort tumefactive demyelination versus primary central nervous system lymphoma on (18)f-fluorodeoxyglucose positron emission tomography magnetic resonance imaging: a twist in the tale
topic Interesting Image
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593932/
https://www.ncbi.nlm.nih.gov/pubmed/31293309
http://dx.doi.org/10.4103/ijnm.IJNM_31_19
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