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Fibrodysplasia Ossificans Progressiva – A Rare Genetic Disorder and the Role of Technetium-99m Methylene Diphosphonate Bone Scan
Fibrodysplasia ossificans progressiva is a rare genetic disease believed to occur in approximately 1 in 2 million people worldwide and is characterized by progressive extraosseous ossification over the course of a lifetime in an inevitable and unpredictable episodic manner, with most patients being...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593934/ https://www.ncbi.nlm.nih.gov/pubmed/31293300 http://dx.doi.org/10.4103/ijnm.IJNM_57_19 |
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author | Gupta, Nitin Pruthi, Ankur Kumar, Suneel Verma, Ritu Belho, Ethel Shangne |
author_facet | Gupta, Nitin Pruthi, Ankur Kumar, Suneel Verma, Ritu Belho, Ethel Shangne |
author_sort | Gupta, Nitin |
collection | PubMed |
description | Fibrodysplasia ossificans progressiva is a rare genetic disease believed to occur in approximately 1 in 2 million people worldwide and is characterized by progressive extraosseous ossification over the course of a lifetime in an inevitable and unpredictable episodic manner, with most patients being confined to a wheelchair by the third decade of life and requiring life-long care. The extraosseous calcification involves ligaments, tendons, muscles, and connective tissue leading to severe restriction of movements. Another hallmark of this condition is abnormal great toes. The diagnosis is often made on clinical and radiological examination, but Technetium-99m methylene diphosphonate (Tc-99m MDP) bone scan is usually indicated to determine the extent of the disease. We hereby present a case series comprising of four patients suffering from this debilitating illness who underwent Tc99m MDP bone scan for initial diagnosis and localizing sites of heterotopic ossification. |
format | Online Article Text |
id | pubmed-6593934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-65939342019-07-11 Fibrodysplasia Ossificans Progressiva – A Rare Genetic Disorder and the Role of Technetium-99m Methylene Diphosphonate Bone Scan Gupta, Nitin Pruthi, Ankur Kumar, Suneel Verma, Ritu Belho, Ethel Shangne Indian J Nucl Med Case Series Fibrodysplasia ossificans progressiva is a rare genetic disease believed to occur in approximately 1 in 2 million people worldwide and is characterized by progressive extraosseous ossification over the course of a lifetime in an inevitable and unpredictable episodic manner, with most patients being confined to a wheelchair by the third decade of life and requiring life-long care. The extraosseous calcification involves ligaments, tendons, muscles, and connective tissue leading to severe restriction of movements. Another hallmark of this condition is abnormal great toes. The diagnosis is often made on clinical and radiological examination, but Technetium-99m methylene diphosphonate (Tc-99m MDP) bone scan is usually indicated to determine the extent of the disease. We hereby present a case series comprising of four patients suffering from this debilitating illness who underwent Tc99m MDP bone scan for initial diagnosis and localizing sites of heterotopic ossification. Medknow Publications & Media Pvt Ltd 2019 /pmc/articles/PMC6593934/ /pubmed/31293300 http://dx.doi.org/10.4103/ijnm.IJNM_57_19 Text en Copyright: © 2019 Indian Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Series Gupta, Nitin Pruthi, Ankur Kumar, Suneel Verma, Ritu Belho, Ethel Shangne Fibrodysplasia Ossificans Progressiva – A Rare Genetic Disorder and the Role of Technetium-99m Methylene Diphosphonate Bone Scan |
title | Fibrodysplasia Ossificans Progressiva – A Rare Genetic Disorder and the Role of Technetium-99m Methylene Diphosphonate Bone Scan |
title_full | Fibrodysplasia Ossificans Progressiva – A Rare Genetic Disorder and the Role of Technetium-99m Methylene Diphosphonate Bone Scan |
title_fullStr | Fibrodysplasia Ossificans Progressiva – A Rare Genetic Disorder and the Role of Technetium-99m Methylene Diphosphonate Bone Scan |
title_full_unstemmed | Fibrodysplasia Ossificans Progressiva – A Rare Genetic Disorder and the Role of Technetium-99m Methylene Diphosphonate Bone Scan |
title_short | Fibrodysplasia Ossificans Progressiva – A Rare Genetic Disorder and the Role of Technetium-99m Methylene Diphosphonate Bone Scan |
title_sort | fibrodysplasia ossificans progressiva – a rare genetic disorder and the role of technetium-99m methylene diphosphonate bone scan |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593934/ https://www.ncbi.nlm.nih.gov/pubmed/31293300 http://dx.doi.org/10.4103/ijnm.IJNM_57_19 |
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