Process monitoring of virus‐like particle reassembly by diafiltration with UV/Vis spectroscopy and light scattering

Virus‐like particles (VLPs) have shown great potential as biopharmaceuticals in the market and in clinics. Nonenveloped, in vivo assembled VLPs are typically disassembled and reassembled in vitro to improve particle stability, homogeneity, and immunogenicity. At the industrial scale, cross‐flow filt...

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Detalles Bibliográficos
Autores principales: Rüdt, Matthias, Vormittag, Philipp, Hillebrandt, Nils, Hubbuch, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593973/
https://www.ncbi.nlm.nih.gov/pubmed/30684365
http://dx.doi.org/10.1002/bit.26935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593973/
https://www.ncbi.nlm.nih.gov/pubmed/30684365
http://dx.doi.org/10.1002/bit.26935

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