Microglia damage precedes major myelin breakdown in X‐linked adrenoleukodystrophy and metachromatic leukodystrophy

X‐linked adrenoleukodystrophy (X‐ALD) and metachromatic leukodystrophy (MLD) are two relatively common examples of hereditary demyelinating diseases caused by a dysfunction of peroxisomal or lysosomal lipid degradation. In both conditions, accumulation of nondegraded lipids leads to the destruction...

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Detalles Bibliográficos
Autores principales: Bergner, Caroline G., van der Meer, Franziska, Winkler, Anne, Wrzos, Claudia, Türkmen, Mevlude, Valizada, Emil, Fitzner, Dirk, Hametner, Simon, Hartmann, Christian, Pfeifenbring, Sabine, Stoltenburg‐Didinger, Gisela, Brück, Wolfgang, Nessler, Stefan, Stadelmann, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594046/
https://www.ncbi.nlm.nih.gov/pubmed/30980503
http://dx.doi.org/10.1002/glia.23598

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