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Body Composition, Metabolic Characteristics, and Insulin Resistance in Obese and Nonobese Women with Polycystic Ovary Syndrome

OBJECTIVES: The objective was to compare body composition, metabolic characteristics, and insulin resistance between obese (body mass index [BMI] ≥25 kg/m(2)) polycystic ovary syndrome (PCOS) and nonobese PCOS (BMI <25 kg/m(2)) women and their age- and BMI-matched controls. MATERIALS AND METHODS:...

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Autores principales: Satyaraddi, Anil, Cherian, Kripa Elizabeth, Kapoor, Nitin, Kunjummen, Aleyamma Thaiparambil, Kamath, Mohan S., Thomas, Nihal, Paul, Thomas V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594114/
https://www.ncbi.nlm.nih.gov/pubmed/31293320
http://dx.doi.org/10.4103/jhrs.JHRS_2_19
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author Satyaraddi, Anil
Cherian, Kripa Elizabeth
Kapoor, Nitin
Kunjummen, Aleyamma Thaiparambil
Kamath, Mohan S.
Thomas, Nihal
Paul, Thomas V.
author_facet Satyaraddi, Anil
Cherian, Kripa Elizabeth
Kapoor, Nitin
Kunjummen, Aleyamma Thaiparambil
Kamath, Mohan S.
Thomas, Nihal
Paul, Thomas V.
author_sort Satyaraddi, Anil
collection PubMed
description OBJECTIVES: The objective was to compare body composition, metabolic characteristics, and insulin resistance between obese (body mass index [BMI] ≥25 kg/m(2)) polycystic ovary syndrome (PCOS) and nonobese PCOS (BMI <25 kg/m(2)) women and their age- and BMI-matched controls. MATERIALS AND METHODS: A total of 81 PCOS women (Rotterdam criteria) (obese – 42; nonobese – 39) and 86 controls (obese – 42; nonobese –44) were recruited in this cross-sectional study. All women underwent a detailed assessment of clinical, anthropometric, and metabolic parameters, insulin resistance indices, and body composition measurements with visceral adipose tissue assessment (VAT) (dual-energy X-ray absorptiometry scan). RESULTS: Of PCOS women, 27% (80% – obese PCOS; 20% – nonobese PCOS) were diagnosed with metabolic syndrome (International Diabetes Federation criteria), 35% of PCOS women (46% – obese PCOS; 54% – nonobese PCOS) had impaired glucose tolerance, and 7% of PCOS women (2/3(rd) – obese PCOS; 1/3(rd) – nonobese PCOS) had diabetes mellitus. Insulin resistance was seen in about 80% in obese PCOS women and 20% in nonobese PCOS women based on various insulin resistance indices such as fasting insulin (≥12.2 μU/ml), Homeostasis Model Assessment-Insulin Resistance (≥2.5), and Quantitative Insulin Sensitivity Check Index (<0.33). Total body fat, estimated (Est.) VAT, and corrected Est. VAT (corrected for body weight) were significantly increased (P = 0.0001) in both obese and nonobese PCOS women when compared to those of their age- and BMI-matched controls. However, corrected Est. VAT (corrected for body weight) was not significantly different between obese and nonobese PCOS women. CONCLUSION: Both obese and nonobese PCOS women when compared with their age- and BMI-matched controls were metabolically worse and had more visceral adiposity. Nonobese PCOS poses similar risk as that of obese PCOS in having similar amount of VAT (corrected for body weight).
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spelling pubmed-65941142019-07-10 Body Composition, Metabolic Characteristics, and Insulin Resistance in Obese and Nonobese Women with Polycystic Ovary Syndrome Satyaraddi, Anil Cherian, Kripa Elizabeth Kapoor, Nitin Kunjummen, Aleyamma Thaiparambil Kamath, Mohan S. Thomas, Nihal Paul, Thomas V. J Hum Reprod Sci Original Article OBJECTIVES: The objective was to compare body composition, metabolic characteristics, and insulin resistance between obese (body mass index [BMI] ≥25 kg/m(2)) polycystic ovary syndrome (PCOS) and nonobese PCOS (BMI <25 kg/m(2)) women and their age- and BMI-matched controls. MATERIALS AND METHODS: A total of 81 PCOS women (Rotterdam criteria) (obese – 42; nonobese – 39) and 86 controls (obese – 42; nonobese –44) were recruited in this cross-sectional study. All women underwent a detailed assessment of clinical, anthropometric, and metabolic parameters, insulin resistance indices, and body composition measurements with visceral adipose tissue assessment (VAT) (dual-energy X-ray absorptiometry scan). RESULTS: Of PCOS women, 27% (80% – obese PCOS; 20% – nonobese PCOS) were diagnosed with metabolic syndrome (International Diabetes Federation criteria), 35% of PCOS women (46% – obese PCOS; 54% – nonobese PCOS) had impaired glucose tolerance, and 7% of PCOS women (2/3(rd) – obese PCOS; 1/3(rd) – nonobese PCOS) had diabetes mellitus. Insulin resistance was seen in about 80% in obese PCOS women and 20% in nonobese PCOS women based on various insulin resistance indices such as fasting insulin (≥12.2 μU/ml), Homeostasis Model Assessment-Insulin Resistance (≥2.5), and Quantitative Insulin Sensitivity Check Index (<0.33). Total body fat, estimated (Est.) VAT, and corrected Est. VAT (corrected for body weight) were significantly increased (P = 0.0001) in both obese and nonobese PCOS women when compared to those of their age- and BMI-matched controls. However, corrected Est. VAT (corrected for body weight) was not significantly different between obese and nonobese PCOS women. CONCLUSION: Both obese and nonobese PCOS women when compared with their age- and BMI-matched controls were metabolically worse and had more visceral adiposity. Nonobese PCOS poses similar risk as that of obese PCOS in having similar amount of VAT (corrected for body weight). Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6594114/ /pubmed/31293320 http://dx.doi.org/10.4103/jhrs.JHRS_2_19 Text en Copyright: © 2019 Journal of Human Reproductive Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Satyaraddi, Anil
Cherian, Kripa Elizabeth
Kapoor, Nitin
Kunjummen, Aleyamma Thaiparambil
Kamath, Mohan S.
Thomas, Nihal
Paul, Thomas V.
Body Composition, Metabolic Characteristics, and Insulin Resistance in Obese and Nonobese Women with Polycystic Ovary Syndrome
title Body Composition, Metabolic Characteristics, and Insulin Resistance in Obese and Nonobese Women with Polycystic Ovary Syndrome
title_full Body Composition, Metabolic Characteristics, and Insulin Resistance in Obese and Nonobese Women with Polycystic Ovary Syndrome
title_fullStr Body Composition, Metabolic Characteristics, and Insulin Resistance in Obese and Nonobese Women with Polycystic Ovary Syndrome
title_full_unstemmed Body Composition, Metabolic Characteristics, and Insulin Resistance in Obese and Nonobese Women with Polycystic Ovary Syndrome
title_short Body Composition, Metabolic Characteristics, and Insulin Resistance in Obese and Nonobese Women with Polycystic Ovary Syndrome
title_sort body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594114/
https://www.ncbi.nlm.nih.gov/pubmed/31293320
http://dx.doi.org/10.4103/jhrs.JHRS_2_19
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