Cargando…

Wearable Finger Pulse Oximetry for Continuous Oxygen Saturation Measurements During Daily Home Routines of Patients With Chronic Obstructive Pulmonary Disease (COPD) Over One Week: Observational Study

BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients can suffer from low blood oxygen concentrations. Peripheral blood oxygen saturation (SpO(2)), as assessed by pulse oximetry, is commonly measured during the day using a spot check, or continuously during one or two nights to estimate...

Descripción completa

Detalles Bibliográficos
Autores principales: Buekers, Joren, Theunis, Jan, De Boever, Patrick, Vaes, Anouk W, Koopman, Maud, Janssen, Eefje VM, Wouters, Emiel FM, Spruit, Martijn A, Aerts, Jean-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JMIR Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594211/
https://www.ncbi.nlm.nih.gov/pubmed/31199331
http://dx.doi.org/10.2196/12866
_version_ 1783430204044083200
author Buekers, Joren
Theunis, Jan
De Boever, Patrick
Vaes, Anouk W
Koopman, Maud
Janssen, Eefje VM
Wouters, Emiel FM
Spruit, Martijn A
Aerts, Jean-Marie
author_facet Buekers, Joren
Theunis, Jan
De Boever, Patrick
Vaes, Anouk W
Koopman, Maud
Janssen, Eefje VM
Wouters, Emiel FM
Spruit, Martijn A
Aerts, Jean-Marie
author_sort Buekers, Joren
collection PubMed
description BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients can suffer from low blood oxygen concentrations. Peripheral blood oxygen saturation (SpO(2)), as assessed by pulse oximetry, is commonly measured during the day using a spot check, or continuously during one or two nights to estimate nocturnal desaturation. Sampling at this frequency may overlook natural fluctuations in SpO(2). OBJECTIVE: This study used wearable finger pulse oximeters to continuously measure SpO(2) during daily home routines of COPD patients and assess natural SpO(2) fluctuations. METHODS: A total of 20 COPD patients wore a WristOx(2) pulse oximeter for 1 week to collect continuous SpO(2) measurements. A SenseWear Armband simultaneously collected actigraphy measurements to provide contextual information. SpO(2) time series were preprocessed and data quality was assessed afterward. Mean SpO(2), SpO(2) SD, and cumulative time spent with SpO(2) below 90% (CT90) were calculated for every (1) day, (2) day in rest, and (3) night to assess SpO(2) fluctuations. RESULTS: A high percentage of valid SpO(2) data (daytime: 93.27%; nocturnal: 99.31%) could be obtained during a 7-day monitoring period, except during moderate-to-vigorous physical activity (MVPA) (67.86%). Mean nocturnal SpO(2) (89.9%, SD 3.4) was lower than mean daytime SpO(2) in rest (92.1%, SD 2.9; P<.001). On average, SpO(2) in rest ranged over 10.8% (SD 4.4) within one day. Highly varying CT90 values between different nights led to 50% (10/20) of the included patients changing categories between desaturator and nondesaturator over the course of 1 week. CONCLUSIONS: Continuous SpO(2) measurements with wearable finger pulse oximeters identified significant SpO(2) fluctuations between and within multiple days and nights of patients with COPD. Continuous SpO(2) measurements during daily home routines of patients with COPD generally had high amounts of valid data, except for motion artifacts during MVPA. The identified fluctuations can have implications for telemonitoring applications that are based on daily SpO(2) spot checks. CT90 values can vary greatly from night to night in patients with a nocturnal mean SpO(2) around 90%, indicating that these patients cannot be consistently categorized as desaturators or nondesaturators. We recommend using wearable sensors for continuous SpO(2) measurements over longer time periods to determine the clinical relevance of the identified SpO(2) fluctuations.
format Online
Article
Text
id pubmed-6594211
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher JMIR Publications
record_format MEDLINE/PubMed
spelling pubmed-65942112019-07-17 Wearable Finger Pulse Oximetry for Continuous Oxygen Saturation Measurements During Daily Home Routines of Patients With Chronic Obstructive Pulmonary Disease (COPD) Over One Week: Observational Study Buekers, Joren Theunis, Jan De Boever, Patrick Vaes, Anouk W Koopman, Maud Janssen, Eefje VM Wouters, Emiel FM Spruit, Martijn A Aerts, Jean-Marie JMIR Mhealth Uhealth Original Paper BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients can suffer from low blood oxygen concentrations. Peripheral blood oxygen saturation (SpO(2)), as assessed by pulse oximetry, is commonly measured during the day using a spot check, or continuously during one or two nights to estimate nocturnal desaturation. Sampling at this frequency may overlook natural fluctuations in SpO(2). OBJECTIVE: This study used wearable finger pulse oximeters to continuously measure SpO(2) during daily home routines of COPD patients and assess natural SpO(2) fluctuations. METHODS: A total of 20 COPD patients wore a WristOx(2) pulse oximeter for 1 week to collect continuous SpO(2) measurements. A SenseWear Armband simultaneously collected actigraphy measurements to provide contextual information. SpO(2) time series were preprocessed and data quality was assessed afterward. Mean SpO(2), SpO(2) SD, and cumulative time spent with SpO(2) below 90% (CT90) were calculated for every (1) day, (2) day in rest, and (3) night to assess SpO(2) fluctuations. RESULTS: A high percentage of valid SpO(2) data (daytime: 93.27%; nocturnal: 99.31%) could be obtained during a 7-day monitoring period, except during moderate-to-vigorous physical activity (MVPA) (67.86%). Mean nocturnal SpO(2) (89.9%, SD 3.4) was lower than mean daytime SpO(2) in rest (92.1%, SD 2.9; P<.001). On average, SpO(2) in rest ranged over 10.8% (SD 4.4) within one day. Highly varying CT90 values between different nights led to 50% (10/20) of the included patients changing categories between desaturator and nondesaturator over the course of 1 week. CONCLUSIONS: Continuous SpO(2) measurements with wearable finger pulse oximeters identified significant SpO(2) fluctuations between and within multiple days and nights of patients with COPD. Continuous SpO(2) measurements during daily home routines of patients with COPD generally had high amounts of valid data, except for motion artifacts during MVPA. The identified fluctuations can have implications for telemonitoring applications that are based on daily SpO(2) spot checks. CT90 values can vary greatly from night to night in patients with a nocturnal mean SpO(2) around 90%, indicating that these patients cannot be consistently categorized as desaturators or nondesaturators. We recommend using wearable sensors for continuous SpO(2) measurements over longer time periods to determine the clinical relevance of the identified SpO(2) fluctuations. JMIR Publications 2019-06-06 /pmc/articles/PMC6594211/ /pubmed/31199331 http://dx.doi.org/10.2196/12866 Text en ©Joren Buekers, Jan Theunis, Patrick De Boever, Anouk W Vaes, Maud Koopman, Eefje VM Janssen, Emiel FM Wouters, Martijn A Spruit, Jean-Marie Aerts. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 06.06.2019. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mhealth and uhealth, is properly cited. The complete bibliographic information, a link to the original publication on http://mhealth.jmir.org/, as well as this copyright and license information must be included.
spellingShingle Original Paper
Buekers, Joren
Theunis, Jan
De Boever, Patrick
Vaes, Anouk W
Koopman, Maud
Janssen, Eefje VM
Wouters, Emiel FM
Spruit, Martijn A
Aerts, Jean-Marie
Wearable Finger Pulse Oximetry for Continuous Oxygen Saturation Measurements During Daily Home Routines of Patients With Chronic Obstructive Pulmonary Disease (COPD) Over One Week: Observational Study
title Wearable Finger Pulse Oximetry for Continuous Oxygen Saturation Measurements During Daily Home Routines of Patients With Chronic Obstructive Pulmonary Disease (COPD) Over One Week: Observational Study
title_full Wearable Finger Pulse Oximetry for Continuous Oxygen Saturation Measurements During Daily Home Routines of Patients With Chronic Obstructive Pulmonary Disease (COPD) Over One Week: Observational Study
title_fullStr Wearable Finger Pulse Oximetry for Continuous Oxygen Saturation Measurements During Daily Home Routines of Patients With Chronic Obstructive Pulmonary Disease (COPD) Over One Week: Observational Study
title_full_unstemmed Wearable Finger Pulse Oximetry for Continuous Oxygen Saturation Measurements During Daily Home Routines of Patients With Chronic Obstructive Pulmonary Disease (COPD) Over One Week: Observational Study
title_short Wearable Finger Pulse Oximetry for Continuous Oxygen Saturation Measurements During Daily Home Routines of Patients With Chronic Obstructive Pulmonary Disease (COPD) Over One Week: Observational Study
title_sort wearable finger pulse oximetry for continuous oxygen saturation measurements during daily home routines of patients with chronic obstructive pulmonary disease (copd) over one week: observational study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594211/
https://www.ncbi.nlm.nih.gov/pubmed/31199331
http://dx.doi.org/10.2196/12866
work_keys_str_mv AT buekersjoren wearablefingerpulseoximetryforcontinuousoxygensaturationmeasurementsduringdailyhomeroutinesofpatientswithchronicobstructivepulmonarydiseasecopdoveroneweekobservationalstudy
AT theunisjan wearablefingerpulseoximetryforcontinuousoxygensaturationmeasurementsduringdailyhomeroutinesofpatientswithchronicobstructivepulmonarydiseasecopdoveroneweekobservationalstudy
AT deboeverpatrick wearablefingerpulseoximetryforcontinuousoxygensaturationmeasurementsduringdailyhomeroutinesofpatientswithchronicobstructivepulmonarydiseasecopdoveroneweekobservationalstudy
AT vaesanoukw wearablefingerpulseoximetryforcontinuousoxygensaturationmeasurementsduringdailyhomeroutinesofpatientswithchronicobstructivepulmonarydiseasecopdoveroneweekobservationalstudy
AT koopmanmaud wearablefingerpulseoximetryforcontinuousoxygensaturationmeasurementsduringdailyhomeroutinesofpatientswithchronicobstructivepulmonarydiseasecopdoveroneweekobservationalstudy
AT jansseneefjevm wearablefingerpulseoximetryforcontinuousoxygensaturationmeasurementsduringdailyhomeroutinesofpatientswithchronicobstructivepulmonarydiseasecopdoveroneweekobservationalstudy
AT woutersemielfm wearablefingerpulseoximetryforcontinuousoxygensaturationmeasurementsduringdailyhomeroutinesofpatientswithchronicobstructivepulmonarydiseasecopdoveroneweekobservationalstudy
AT spruitmartijna wearablefingerpulseoximetryforcontinuousoxygensaturationmeasurementsduringdailyhomeroutinesofpatientswithchronicobstructivepulmonarydiseasecopdoveroneweekobservationalstudy
AT aertsjeanmarie wearablefingerpulseoximetryforcontinuousoxygensaturationmeasurementsduringdailyhomeroutinesofpatientswithchronicobstructivepulmonarydiseasecopdoveroneweekobservationalstudy