Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes

An effective vaccine is a priority for malaria control and elimination. The leading candidate in the Plasmodium falciparum blood stage is PfRh5. PfRh5 assembles into trimeric complex with PfRipr and PfCyRPA in the parasite, and this complex is essential for erythrocyte invasion. In this study, we sh...

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Detalles Bibliográficos
Autores principales: Healer, Julie, Wong, Wilson, Thompson, Jennifer K., He, Wengqiang, Birkinshaw, Richard W., Miura, Kazutoyo, Long, Carol A., Soroka, Vladislav, Søgaard, Teit Max Moscote, Jørgensen, Thomas, de Jongh, Willem A., Weir, Christopher, Svahn, Ella, Czabotar, Peter E., Tham, Wai‐Hong, Mueller, Ivo, Barlow, Paul N., Cowman, Alan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594224/
https://www.ncbi.nlm.nih.gov/pubmed/30965383
http://dx.doi.org/10.1111/cmi.13030

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