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Potentially inappropriate medications prescribing according to Beers criteria among elderly outpatients in Jordan: a cross sectional study

BACKGROUND: Due to aging, along with its associated physiological changes, older adults are extremely vulnerable to be afflicted with multiple chronic conditions (multimorbidity). Accordingly, prescribing a large number of drugs to older adults would be inevitable. Resulted complex drug regimens can...

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Autores principales: Al-Azayzih, Ahmad, Alamoori, Rawan, Altawalbeh., Shoroq M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centro de Investigaciones y Publicaciones Farmaceuticas 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594439/
https://www.ncbi.nlm.nih.gov/pubmed/31275497
http://dx.doi.org/10.18549/PharmPract.2019.2.1439
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author Al-Azayzih, Ahmad
Alamoori, Rawan
Altawalbeh., Shoroq M.
author_facet Al-Azayzih, Ahmad
Alamoori, Rawan
Altawalbeh., Shoroq M.
author_sort Al-Azayzih, Ahmad
collection PubMed
description BACKGROUND: Due to aging, along with its associated physiological changes, older adults are extremely vulnerable to be afflicted with multiple chronic conditions (multimorbidity). Accordingly, prescribing a large number of drugs to older adults would be inevitable. Resulted complex drug regimens can lead to prescribing of Potentially Inappropriate Medications (PIMs) with subsequent negative health and economic outcomes. OBJECTIVES: The main objective of this study is to investigate the prevalence and predictors of PIMs prescribing among Jordanian elderly outpatients, using the last updated version of the American Geriatrics Society (AGS) Beers Criteria (2015 version). METHODS: A Unicenter, cross-sectional study were data was assessed using medical records of included study subjects conducted over three months period from beginning of October to the end of December 2016 at King Abdullah University Hospital, Al Ramtha, Jordan. Our study included patients aged 65 years or above who visited the outpatient clinics at King Abdullah University hospital (KAUH) and were prescribed at least one oral medication during the study period. PIMs were identified for these patients and further classified according to the 2015 AGS Beers Criteria. We measured the prevalence of PIMs prescribed among elderly outpatients in Jordan. RESULTS: A total of 4622 eligible older adults were evaluated in this study, of whom 62.5% (n=2891) were found to have at least one PIM prescribed during the three months study period. 69% of identified PIMs were medications to be used with caution in elderly, 22% were medications to avoid in many or most older adults, 6.3% were medications to be avoided or have their dosage adjusted based on kidney function in older adults, 2.04% medications were to avoid in older adults with specific diseases/syndromes, and 1.6% were potentially clinically important non-anti-infective drug-drug interactions to be avoided in older adults. Female gender and polypharmacy were found to be significant predictors of PIMs use among elderly. CONCLUSIONS: Potentially Inappropriate Medication prescribing is common among Jordanian elderly outpatients. Female gender and polypharmacy are associated with more PIMs prescribing and so need further attention.
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spelling pubmed-65944392019-07-02 Potentially inappropriate medications prescribing according to Beers criteria among elderly outpatients in Jordan: a cross sectional study Al-Azayzih, Ahmad Alamoori, Rawan Altawalbeh., Shoroq M. Pharm Pract (Granada) Original Research BACKGROUND: Due to aging, along with its associated physiological changes, older adults are extremely vulnerable to be afflicted with multiple chronic conditions (multimorbidity). Accordingly, prescribing a large number of drugs to older adults would be inevitable. Resulted complex drug regimens can lead to prescribing of Potentially Inappropriate Medications (PIMs) with subsequent negative health and economic outcomes. OBJECTIVES: The main objective of this study is to investigate the prevalence and predictors of PIMs prescribing among Jordanian elderly outpatients, using the last updated version of the American Geriatrics Society (AGS) Beers Criteria (2015 version). METHODS: A Unicenter, cross-sectional study were data was assessed using medical records of included study subjects conducted over three months period from beginning of October to the end of December 2016 at King Abdullah University Hospital, Al Ramtha, Jordan. Our study included patients aged 65 years or above who visited the outpatient clinics at King Abdullah University hospital (KAUH) and were prescribed at least one oral medication during the study period. PIMs were identified for these patients and further classified according to the 2015 AGS Beers Criteria. We measured the prevalence of PIMs prescribed among elderly outpatients in Jordan. RESULTS: A total of 4622 eligible older adults were evaluated in this study, of whom 62.5% (n=2891) were found to have at least one PIM prescribed during the three months study period. 69% of identified PIMs were medications to be used with caution in elderly, 22% were medications to avoid in many or most older adults, 6.3% were medications to be avoided or have their dosage adjusted based on kidney function in older adults, 2.04% medications were to avoid in older adults with specific diseases/syndromes, and 1.6% were potentially clinically important non-anti-infective drug-drug interactions to be avoided in older adults. Female gender and polypharmacy were found to be significant predictors of PIMs use among elderly. CONCLUSIONS: Potentially Inappropriate Medication prescribing is common among Jordanian elderly outpatients. Female gender and polypharmacy are associated with more PIMs prescribing and so need further attention. Centro de Investigaciones y Publicaciones Farmaceuticas 2019 2019-06-05 /pmc/articles/PMC6594439/ /pubmed/31275497 http://dx.doi.org/10.18549/PharmPract.2019.2.1439 Text en Copyright: © Pharmacy Practice http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY-NC-ND 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Al-Azayzih, Ahmad
Alamoori, Rawan
Altawalbeh., Shoroq M.
Potentially inappropriate medications prescribing according to Beers criteria among elderly outpatients in Jordan: a cross sectional study
title Potentially inappropriate medications prescribing according to Beers criteria among elderly outpatients in Jordan: a cross sectional study
title_full Potentially inappropriate medications prescribing according to Beers criteria among elderly outpatients in Jordan: a cross sectional study
title_fullStr Potentially inappropriate medications prescribing according to Beers criteria among elderly outpatients in Jordan: a cross sectional study
title_full_unstemmed Potentially inappropriate medications prescribing according to Beers criteria among elderly outpatients in Jordan: a cross sectional study
title_short Potentially inappropriate medications prescribing according to Beers criteria among elderly outpatients in Jordan: a cross sectional study
title_sort potentially inappropriate medications prescribing according to beers criteria among elderly outpatients in jordan: a cross sectional study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594439/
https://www.ncbi.nlm.nih.gov/pubmed/31275497
http://dx.doi.org/10.18549/PharmPract.2019.2.1439
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