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The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation
Applying pre-steady state kinetics to an Escherichia-coli-based reconstituted translation system, we have studied how the antibiotic viomycin affects the accuracy of genetic code reading. We find that viomycin binds to translating ribosomes associated with a ternary complex (TC) consisting of elonga...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594751/ https://www.ncbi.nlm.nih.gov/pubmed/31172942 http://dx.doi.org/10.7554/eLife.46124 |