Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

In amyotrophic lateral sclerosis (ALS) spinal motor neurons (SpMN) progressively degenerate while a subset of cranial motor neurons (CrMN) are spared until late stages of the disease. Using a rapid and efficient protocol to differentiate mouse embryonic stem cells (ESC) to SpMNs and CrMNs, we now re...

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Detalles Bibliográficos
Autores principales: An, Disi, Fujiki, Ryosuke, Iannitelli, Dylan E, Smerdon, John W, Maity, Shuvadeep, Rose, Matthew F, Gelber, Alon, Wanaselja, Elizabeth K, Yagudayeva, Ilona, Lee, Joun Y, Vogel, Christine, Wichterle, Hynek, Engle, Elizabeth C, Mazzoni, Esteban Orlando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594754/
https://www.ncbi.nlm.nih.gov/pubmed/31157617
http://dx.doi.org/10.7554/eLife.44423

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