Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control

E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mec...

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Detalles Bibliográficos
Autores principales: Roworth, Alice Poppy, Carr, Simon Mark, Liu, Geng, Barczak, Wojciech, Miller, Rebecca Louise, Munro, Shonagh, Kanapin, Alexander, Samsonova, Anastasia, La Thangue, Nicholas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594773/
https://www.ncbi.nlm.nih.gov/pubmed/31249870
http://dx.doi.org/10.1126/sciadv.aaw4640

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