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Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion
Melanoma is a highly aggressive cancer that exhibits metastasis to various critical organs. Unlike any other cancer cells, melanoma cells can synthesize melanin in large amounts, becoming heavily pigmented. Until now the role of melanin in melanoma, particularly the effect of melanin presence on the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594928/ https://www.ncbi.nlm.nih.gov/pubmed/31243305 http://dx.doi.org/10.1038/s41598-019-45643-9 |
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author | Sarna, Michal Krzykawska-Serda, Martyna Jakubowska, Monika Zadlo, Andrzej Urbanska, Krystyna |
author_facet | Sarna, Michal Krzykawska-Serda, Martyna Jakubowska, Monika Zadlo, Andrzej Urbanska, Krystyna |
author_sort | Sarna, Michal |
collection | PubMed |
description | Melanoma is a highly aggressive cancer that exhibits metastasis to various critical organs. Unlike any other cancer cells, melanoma cells can synthesize melanin in large amounts, becoming heavily pigmented. Until now the role of melanin in melanoma, particularly the effect of melanin presence on the abilities of melanoma cells to spread and metastasize remains unknown. Recently, we have shown that melanin dramatically modified elastic properties of melanoma cells and inhibited the cells invasive abilities in vitro. Here, we inoculated human melanoma cells with different melanin content into nude mice and tested the hypothesis that cell elasticity is an important property of cancer cells for their efficient spread in vivo. The obtained results clearly showed that cells containing melanin were less capable to spread in mice than cells without the pigment. Our findings indicate that the presence of melanin inhibits melanoma metastasis, emphasizing possible clinical implications of such an inhibitory effect. |
format | Online Article Text |
id | pubmed-6594928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65949282019-07-03 Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion Sarna, Michal Krzykawska-Serda, Martyna Jakubowska, Monika Zadlo, Andrzej Urbanska, Krystyna Sci Rep Article Melanoma is a highly aggressive cancer that exhibits metastasis to various critical organs. Unlike any other cancer cells, melanoma cells can synthesize melanin in large amounts, becoming heavily pigmented. Until now the role of melanin in melanoma, particularly the effect of melanin presence on the abilities of melanoma cells to spread and metastasize remains unknown. Recently, we have shown that melanin dramatically modified elastic properties of melanoma cells and inhibited the cells invasive abilities in vitro. Here, we inoculated human melanoma cells with different melanin content into nude mice and tested the hypothesis that cell elasticity is an important property of cancer cells for their efficient spread in vivo. The obtained results clearly showed that cells containing melanin were less capable to spread in mice than cells without the pigment. Our findings indicate that the presence of melanin inhibits melanoma metastasis, emphasizing possible clinical implications of such an inhibitory effect. Nature Publishing Group UK 2019-06-26 /pmc/articles/PMC6594928/ /pubmed/31243305 http://dx.doi.org/10.1038/s41598-019-45643-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Sarna, Michal Krzykawska-Serda, Martyna Jakubowska, Monika Zadlo, Andrzej Urbanska, Krystyna Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion |
title | Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion |
title_full | Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion |
title_fullStr | Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion |
title_full_unstemmed | Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion |
title_short | Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion |
title_sort | melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594928/ https://www.ncbi.nlm.nih.gov/pubmed/31243305 http://dx.doi.org/10.1038/s41598-019-45643-9 |
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