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Piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions

Palpable thyroid lesions are common, and although mostly benign, lethal malignant nodules do occur and may be difficult to differentiate. Here, we introduce the use of a piezoelectric system called Smart-touch fine needle (or STFN) mounted directly onto conventional biopsy needles, to evaluate abnor...

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Autores principales: Sharma, Shivani, Aguilera, Renato, Rao, JianYu, Gimzewski, James K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594950/
https://www.ncbi.nlm.nih.gov/pubmed/31243301
http://dx.doi.org/10.1038/s41598-019-45730-x
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author Sharma, Shivani
Aguilera, Renato
Rao, JianYu
Gimzewski, James K.
author_facet Sharma, Shivani
Aguilera, Renato
Rao, JianYu
Gimzewski, James K.
author_sort Sharma, Shivani
collection PubMed
description Palpable thyroid lesions are common, and although mostly benign, lethal malignant nodules do occur and may be difficult to differentiate. Here, we introduce the use of a piezoelectric system called Smart-touch fine needle (or STFN) mounted directly onto conventional biopsy needles, to evaluate abnormal tissues, through quantitative real-time measurements of variations in tissue stiffness as the needle penetrates tissue. Using well-characterized biomaterials of known stiffness and explanted animal tissue models, we first established experimental protocols for STFN measures on biological tissues, as well as optimized device design for high signal-to-noise ratio. Freshly excised patient thyroids with varying fibrotic and malignant potential revealed discrete variations in STFN based tissue stiffness/stiffness heterogeneity and correlated well with final histopathology. Our piezoelectric needle sensor reveals mechanical heterogeneity in thyroid tissue lesions and provides a foundation for the design of hand-held tools for the rapid, mechano-profiling of malignant lesions in vivo while performing fine needle aspiration (FNA).
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spelling pubmed-65949502019-07-03 Piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions Sharma, Shivani Aguilera, Renato Rao, JianYu Gimzewski, James K. Sci Rep Article Palpable thyroid lesions are common, and although mostly benign, lethal malignant nodules do occur and may be difficult to differentiate. Here, we introduce the use of a piezoelectric system called Smart-touch fine needle (or STFN) mounted directly onto conventional biopsy needles, to evaluate abnormal tissues, through quantitative real-time measurements of variations in tissue stiffness as the needle penetrates tissue. Using well-characterized biomaterials of known stiffness and explanted animal tissue models, we first established experimental protocols for STFN measures on biological tissues, as well as optimized device design for high signal-to-noise ratio. Freshly excised patient thyroids with varying fibrotic and malignant potential revealed discrete variations in STFN based tissue stiffness/stiffness heterogeneity and correlated well with final histopathology. Our piezoelectric needle sensor reveals mechanical heterogeneity in thyroid tissue lesions and provides a foundation for the design of hand-held tools for the rapid, mechano-profiling of malignant lesions in vivo while performing fine needle aspiration (FNA). Nature Publishing Group UK 2019-06-26 /pmc/articles/PMC6594950/ /pubmed/31243301 http://dx.doi.org/10.1038/s41598-019-45730-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sharma, Shivani
Aguilera, Renato
Rao, JianYu
Gimzewski, James K.
Piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions
title Piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions
title_full Piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions
title_fullStr Piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions
title_full_unstemmed Piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions
title_short Piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions
title_sort piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594950/
https://www.ncbi.nlm.nih.gov/pubmed/31243301
http://dx.doi.org/10.1038/s41598-019-45730-x
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