The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal cancer

Therapy-refractory disease is one of the main contributors of treatment failure in cancer. In colorectal cancer (CRC), SPARC can function as a sensitizer to conventional chemotherapy by enhancing apoptosis by interfering with the activity of Bcl-2. Here, we examine a novel mechanism by which SPARC f...

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Detalles Bibliográficos
Autores principales: Chern, Yi-Jye, Wong, John C. T., Cheng, Grace S. W., Yu, Angel, Yin, Yaling, Schaeffer, David F., Kennecke, Hagen F., Morin, Gregg, Tai, Isabella T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594974/
https://www.ncbi.nlm.nih.gov/pubmed/31243264
http://dx.doi.org/10.1038/s41419-019-1687-x

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