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HPV infections and flat penile lesions of the penis in men who have sex with men

BACKGROUND: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). METHODS: In 2015–2016, MSM were recruited based on HIV and...

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Autores principales: Van Bilsen, Ward P.H., Kovaleva, Alexandra, Bleeker, Maaike C.G., King, Audrey J., Bruisten, Sylvia M., Brokking, Wilma, De Vries, Henry J.C., Meijer, Chris J.L.M., Schim Van Der Loeff, Maarten F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595232/
https://www.ncbi.nlm.nih.gov/pubmed/31226447
http://dx.doi.org/10.1016/j.pvr.2019.100173
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author Van Bilsen, Ward P.H.
Kovaleva, Alexandra
Bleeker, Maaike C.G.
King, Audrey J.
Bruisten, Sylvia M.
Brokking, Wilma
De Vries, Henry J.C.
Meijer, Chris J.L.M.
Schim Van Der Loeff, Maarten F.
author_facet Van Bilsen, Ward P.H.
Kovaleva, Alexandra
Bleeker, Maaike C.G.
King, Audrey J.
Bruisten, Sylvia M.
Brokking, Wilma
De Vries, Henry J.C.
Meijer, Chris J.L.M.
Schim Van Der Loeff, Maarten F.
author_sort Van Bilsen, Ward P.H.
collection PubMed
description BACKGROUND: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). METHODS: In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous cohort. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. HPV viral load (VL) was determined using a quantitative type-specific (q)PCR targeting the L1-region. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL. RESULTS: We included 116 MSM, of whom 59/116 (51%) MSM were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and 34/62 (55%) MSM without FPL (p = 0.8). There was no difference between MSM with and without FPL regarding presence of penile HPV infection, HPV VL, HIV status or circumcision status (p > 0.05 for all). CONCLUSION: Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status.
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spelling pubmed-65952322019-07-10 HPV infections and flat penile lesions of the penis in men who have sex with men Van Bilsen, Ward P.H. Kovaleva, Alexandra Bleeker, Maaike C.G. King, Audrey J. Bruisten, Sylvia M. Brokking, Wilma De Vries, Henry J.C. Meijer, Chris J.L.M. Schim Van Der Loeff, Maarten F. Papillomavirus Res Article BACKGROUND: Flat penile lesions (FPL) in heterosexual men are thought to play a role in the transmission of HPV. We investigated the association between FPL and penile HPV, and explored determinants of FPL in men who have sex with men (MSM). METHODS: In 2015–2016, MSM were recruited based on HIV and penile HPV status in a previous cohort. MSM self-completed a questionnaire. Peniscopy was performed after application of acetic acid to visualize FPL. Penile physician-collected samples were tested for HPV-DNA using the highly sensitive SPF10-PCR DEIA/LiPA25 system. HPV viral load (VL) was determined using a quantitative type-specific (q)PCR targeting the L1-region. Presence of HPV and HIV, HPV VL and circumcision status were compared between MSM with and without FPL. RESULTS: We included 116 MSM, of whom 59/116 (51%) MSM were HIV-positive and 54/116 (47%) had FPL. A penile HPV infection was present in 31/54 (57%) MSM with FPL and 34/62 (55%) MSM without FPL (p = 0.8). There was no difference between MSM with and without FPL regarding presence of penile HPV infection, HPV VL, HIV status or circumcision status (p > 0.05 for all). CONCLUSION: Among MSM in Amsterdam, we found no association between FPL and penile HPV, HPV VL, HIV status or circumcision status. Elsevier 2019-06-18 /pmc/articles/PMC6595232/ /pubmed/31226447 http://dx.doi.org/10.1016/j.pvr.2019.100173 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Van Bilsen, Ward P.H.
Kovaleva, Alexandra
Bleeker, Maaike C.G.
King, Audrey J.
Bruisten, Sylvia M.
Brokking, Wilma
De Vries, Henry J.C.
Meijer, Chris J.L.M.
Schim Van Der Loeff, Maarten F.
HPV infections and flat penile lesions of the penis in men who have sex with men
title HPV infections and flat penile lesions of the penis in men who have sex with men
title_full HPV infections and flat penile lesions of the penis in men who have sex with men
title_fullStr HPV infections and flat penile lesions of the penis in men who have sex with men
title_full_unstemmed HPV infections and flat penile lesions of the penis in men who have sex with men
title_short HPV infections and flat penile lesions of the penis in men who have sex with men
title_sort hpv infections and flat penile lesions of the penis in men who have sex with men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595232/
https://www.ncbi.nlm.nih.gov/pubmed/31226447
http://dx.doi.org/10.1016/j.pvr.2019.100173
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