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The association of five preoperative serum tumor markers and pathological features in patients with breast cancer

BACKGROUND: The utility of frequently used serum tumor markers in breast cancer remains controversial. The study aimed to investigate the role of preoperative carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), cancer antigen 153 (CA153), cancer antigen 724 (CA724), and ferritin (FER) in the...

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Autores principales: Lian, Mingjian, Zhang, Cuixia, Zhang, Dongdong, Chen, Ping, Yang, Huijing, Yang, Yuanyuan, Chen, Shidong, Hong, Guolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595372/
https://www.ncbi.nlm.nih.gov/pubmed/30843272
http://dx.doi.org/10.1002/jcla.22875
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author Lian, Mingjian
Zhang, Cuixia
Zhang, Dongdong
Chen, Ping
Yang, Huijing
Yang, Yuanyuan
Chen, Shidong
Hong, Guolin
author_facet Lian, Mingjian
Zhang, Cuixia
Zhang, Dongdong
Chen, Ping
Yang, Huijing
Yang, Yuanyuan
Chen, Shidong
Hong, Guolin
author_sort Lian, Mingjian
collection PubMed
description BACKGROUND: The utility of frequently used serum tumor markers in breast cancer remains controversial. The study aimed to investigate the role of preoperative carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), cancer antigen 153 (CA153), cancer antigen 724 (CA724), and ferritin (FER) in the management of breast cancer and their relationships with pathological features. METHODS: A total of 804 patients with breast mass who underwent breast surgery and 305 healthy volunteers were enrolled. Preoperative serum levels of CEA, CA125, CA153, CA724, and FER were measured. And the pathological features of all the patients were recorded. The association of preoperative serum tumor markers and pathological features was analyzed. RESULTS: Among the 804 patients, 355 were identified as malignant cases and 449 as benign cases. CEA, CA153, and FER of patients with breast cancer were higher than those of healthy volunteer group and patients with benign breast diseases. The area under curve (AUC) of CEA, CA153, and FER for distinguishing patients with breast cancer and subjects with non‐breast cancer was 0.688 (95% CI: 0.656‐0.721), 0.609 (95% CI: 0.574‐0.645), and 0.623 (95% CI: 0.586‐0.660), respectively. CA153 correlated with tumor size, node status, and TNM stage, whereas CA125 with node status. No statistic differences of the five markers were observed among the four molecular subtypes. CONCLUSION: Preoperative levels of CEA, CA153, and FER exhibit low diagnostic accuracy for breast cancer (stage I‐III). CA153 correlates with tumor burden, suggesting its prognostic value. The five serum markers do not correlate with molecular subtypes.
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spelling pubmed-65953722019-11-12 The association of five preoperative serum tumor markers and pathological features in patients with breast cancer Lian, Mingjian Zhang, Cuixia Zhang, Dongdong Chen, Ping Yang, Huijing Yang, Yuanyuan Chen, Shidong Hong, Guolin J Clin Lab Anal Research Articles BACKGROUND: The utility of frequently used serum tumor markers in breast cancer remains controversial. The study aimed to investigate the role of preoperative carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), cancer antigen 153 (CA153), cancer antigen 724 (CA724), and ferritin (FER) in the management of breast cancer and their relationships with pathological features. METHODS: A total of 804 patients with breast mass who underwent breast surgery and 305 healthy volunteers were enrolled. Preoperative serum levels of CEA, CA125, CA153, CA724, and FER were measured. And the pathological features of all the patients were recorded. The association of preoperative serum tumor markers and pathological features was analyzed. RESULTS: Among the 804 patients, 355 were identified as malignant cases and 449 as benign cases. CEA, CA153, and FER of patients with breast cancer were higher than those of healthy volunteer group and patients with benign breast diseases. The area under curve (AUC) of CEA, CA153, and FER for distinguishing patients with breast cancer and subjects with non‐breast cancer was 0.688 (95% CI: 0.656‐0.721), 0.609 (95% CI: 0.574‐0.645), and 0.623 (95% CI: 0.586‐0.660), respectively. CA153 correlated with tumor size, node status, and TNM stage, whereas CA125 with node status. No statistic differences of the five markers were observed among the four molecular subtypes. CONCLUSION: Preoperative levels of CEA, CA153, and FER exhibit low diagnostic accuracy for breast cancer (stage I‐III). CA153 correlates with tumor burden, suggesting its prognostic value. The five serum markers do not correlate with molecular subtypes. John Wiley and Sons Inc. 2019-03-06 /pmc/articles/PMC6595372/ /pubmed/30843272 http://dx.doi.org/10.1002/jcla.22875 Text en © 2019 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Lian, Mingjian
Zhang, Cuixia
Zhang, Dongdong
Chen, Ping
Yang, Huijing
Yang, Yuanyuan
Chen, Shidong
Hong, Guolin
The association of five preoperative serum tumor markers and pathological features in patients with breast cancer
title The association of five preoperative serum tumor markers and pathological features in patients with breast cancer
title_full The association of five preoperative serum tumor markers and pathological features in patients with breast cancer
title_fullStr The association of five preoperative serum tumor markers and pathological features in patients with breast cancer
title_full_unstemmed The association of five preoperative serum tumor markers and pathological features in patients with breast cancer
title_short The association of five preoperative serum tumor markers and pathological features in patients with breast cancer
title_sort association of five preoperative serum tumor markers and pathological features in patients with breast cancer
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595372/
https://www.ncbi.nlm.nih.gov/pubmed/30843272
http://dx.doi.org/10.1002/jcla.22875
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