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Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study
This work proposes and computationally investigate the use of magnetic neural stimulation as an alternative to electrical stimulation to achieve selective activation of rat sciatic nerve. In particular, they assess the effectiveness of an array of small coils to obtain selective neural stimulation,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Institution of Engineering and Technology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595541/ https://www.ncbi.nlm.nih.gov/pubmed/31341631 http://dx.doi.org/10.1049/htl.2018.5020 |
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author | Kosta, Pragya Warren, David J. Lazzi, Gianluca |
author_facet | Kosta, Pragya Warren, David J. Lazzi, Gianluca |
author_sort | Kosta, Pragya |
collection | PubMed |
description | This work proposes and computationally investigate the use of magnetic neural stimulation as an alternative to electrical stimulation to achieve selective activation of rat sciatic nerve. In particular, they assess the effectiveness of an array of small coils to obtain selective neural stimulation, as compared to a single coil. Specifically, an array of four mm-sized coils is used to stimulate rat sciatic nerve, targeting the regions of fascicles that are associated with different muscles of the leg. To evaluate the selectivity of activation, a three-dimensional heterogeneous multi-resolution nerve model is implemented using the impedance method for the computation of the magnetic and electric fields in the nerve. The performance metric ‘selectivity index’ is defined that measures the recruitment of the targeted region compared to other non-targeted regions of the nerve. The selectivity index takes values between −1 (least selective) and 1 (most selective). For each targeted region, a selectivity index of 0.75 or better is predicted for the proposed array configuration. The results suggest that an array of coils can provide superior spatial control of the electric field induced in the neural tissue compared to traditional extraneural electrode arrays, thus opening the possibility to applications where selective neurostimulation is of interest. |
format | Online Article Text |
id | pubmed-6595541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Institution of Engineering and Technology |
record_format | MEDLINE/PubMed |
spelling | pubmed-65955412019-07-24 Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study Kosta, Pragya Warren, David J. Lazzi, Gianluca Healthc Technol Lett Article This work proposes and computationally investigate the use of magnetic neural stimulation as an alternative to electrical stimulation to achieve selective activation of rat sciatic nerve. In particular, they assess the effectiveness of an array of small coils to obtain selective neural stimulation, as compared to a single coil. Specifically, an array of four mm-sized coils is used to stimulate rat sciatic nerve, targeting the regions of fascicles that are associated with different muscles of the leg. To evaluate the selectivity of activation, a three-dimensional heterogeneous multi-resolution nerve model is implemented using the impedance method for the computation of the magnetic and electric fields in the nerve. The performance metric ‘selectivity index’ is defined that measures the recruitment of the targeted region compared to other non-targeted regions of the nerve. The selectivity index takes values between −1 (least selective) and 1 (most selective). For each targeted region, a selectivity index of 0.75 or better is predicted for the proposed array configuration. The results suggest that an array of coils can provide superior spatial control of the electric field induced in the neural tissue compared to traditional extraneural electrode arrays, thus opening the possibility to applications where selective neurostimulation is of interest. The Institution of Engineering and Technology 2019-06-03 /pmc/articles/PMC6595541/ /pubmed/31341631 http://dx.doi.org/10.1049/htl.2018.5020 Text en http://creativecommons.org/licenses/by/3.0/ This is an open access article published by the IET under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) |
spellingShingle | Article Kosta, Pragya Warren, David J. Lazzi, Gianluca Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study |
title | Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study |
title_full | Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study |
title_fullStr | Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study |
title_full_unstemmed | Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study |
title_short | Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study |
title_sort | selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595541/ https://www.ncbi.nlm.nih.gov/pubmed/31341631 http://dx.doi.org/10.1049/htl.2018.5020 |
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