Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

BACKGROUND: Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even more in regions with lower level of perinatal care. The only established therap...

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Detalles Bibliográficos
Autores principales: Maiwald, Christian A., Annink, Kim V., Rüdiger, Mario, Benders, Manon J. N. L., van Bel, Frank, Allegaert, Karel, Naulaers, Gunnar, Bassler, Dirk, Klebermaß-Schrehof, Katrin, Vento, Maximo, Guimarães, Hercilia, Stiris, Tom, Cattarossi, Luigi, Metsäranta, Marjo, Vanhatalo, Sampsa, Mazela, Jan, Metsvaht, Tuuli, Jacobs, Yannique, Franz, Axel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595623/
https://www.ncbi.nlm.nih.gov/pubmed/31248390
http://dx.doi.org/10.1186/s12887-019-1566-8

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