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Development of temperature controller-integrated portable HIFU driver for thermal coagulation
BACKGROUND: Temperature monitoring during high-intensity focused ultrasound (HIFU) therapy on tissue is essential to regulate the degree of thermal coagulation and to achieve the desired treatment outcomes eventually. The aim of the current study was to design and investigate the feasibility of a pr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595699/ https://www.ncbi.nlm.nih.gov/pubmed/31242902 http://dx.doi.org/10.1186/s12938-019-0697-3 |
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author | Park, Suhyun Pham, Ngot Thi Huynh, Huu-Toan Kang, Hyun Wook |
author_facet | Park, Suhyun Pham, Ngot Thi Huynh, Huu-Toan Kang, Hyun Wook |
author_sort | Park, Suhyun |
collection | PubMed |
description | BACKGROUND: Temperature monitoring during high-intensity focused ultrasound (HIFU) therapy on tissue is essential to regulate the degree of thermal coagulation and to achieve the desired treatment outcomes eventually. The aim of the current study was to design and investigate the feasibility of a proportional–integral–derivative (PID) temperature controller-integrated portable HIFU driver for thermal coagulation. METHODS: A portable HIFU driver was designed and operated at a maximum output voltage of 50 V with pulse-width modulation signals at 2 MHz. The temperature of ex vivo bovine liver tissue was monitored using a K-type thermocouple during the 2-MHz HIFU exposure. RESULTS: The tissue temperature was maintained at 60 °C using a PID controller-integrated HIFU driver that modulated the output voltage during the 300-s HIFU exposure. The ex vivo testing demonstrated that the tissue temperature at the focal point approached the chosen temperature, i.e., 60 °C, within 70 s. The temperature was maintained with a deviation of less than 4 °C until the HIFU driver voltage was turned off at 300 s. CONCLUSIONS: The designed PID controller-integrated HIFU driver can be used as a small portable tool to regulate the tissue temperature in real time and achieve thermal coagulation via HIFU sonication. |
format | Online Article Text |
id | pubmed-6595699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65956992019-08-07 Development of temperature controller-integrated portable HIFU driver for thermal coagulation Park, Suhyun Pham, Ngot Thi Huynh, Huu-Toan Kang, Hyun Wook Biomed Eng Online Research BACKGROUND: Temperature monitoring during high-intensity focused ultrasound (HIFU) therapy on tissue is essential to regulate the degree of thermal coagulation and to achieve the desired treatment outcomes eventually. The aim of the current study was to design and investigate the feasibility of a proportional–integral–derivative (PID) temperature controller-integrated portable HIFU driver for thermal coagulation. METHODS: A portable HIFU driver was designed and operated at a maximum output voltage of 50 V with pulse-width modulation signals at 2 MHz. The temperature of ex vivo bovine liver tissue was monitored using a K-type thermocouple during the 2-MHz HIFU exposure. RESULTS: The tissue temperature was maintained at 60 °C using a PID controller-integrated HIFU driver that modulated the output voltage during the 300-s HIFU exposure. The ex vivo testing demonstrated that the tissue temperature at the focal point approached the chosen temperature, i.e., 60 °C, within 70 s. The temperature was maintained with a deviation of less than 4 °C until the HIFU driver voltage was turned off at 300 s. CONCLUSIONS: The designed PID controller-integrated HIFU driver can be used as a small portable tool to regulate the tissue temperature in real time and achieve thermal coagulation via HIFU sonication. BioMed Central 2019-06-26 /pmc/articles/PMC6595699/ /pubmed/31242902 http://dx.doi.org/10.1186/s12938-019-0697-3 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Park, Suhyun Pham, Ngot Thi Huynh, Huu-Toan Kang, Hyun Wook Development of temperature controller-integrated portable HIFU driver for thermal coagulation |
title | Development of temperature controller-integrated portable HIFU driver for thermal coagulation |
title_full | Development of temperature controller-integrated portable HIFU driver for thermal coagulation |
title_fullStr | Development of temperature controller-integrated portable HIFU driver for thermal coagulation |
title_full_unstemmed | Development of temperature controller-integrated portable HIFU driver for thermal coagulation |
title_short | Development of temperature controller-integrated portable HIFU driver for thermal coagulation |
title_sort | development of temperature controller-integrated portable hifu driver for thermal coagulation |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595699/ https://www.ncbi.nlm.nih.gov/pubmed/31242902 http://dx.doi.org/10.1186/s12938-019-0697-3 |
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