Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H(2)O(2) emission during impaired oxidative phosphorylation

BACKGROUND: Muscle wasting and weakness in Duchenne muscular dystrophy (DMD) causes severe locomotor limitations and early death due in part to respiratory muscle failure. Given that current clinical practice focuses on treating secondary complications in this genetic disease, there is a clear need...

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Detalles Bibliográficos
Autores principales: Hughes, Meghan C., Ramos, Sofhia V., Turnbull, Patrick C., Rebalka, Irena A., Cao, Andrew, Monaco, Cynthia M.F., Varah, Nina E., Edgett, Brittany A., Huber, Jason S., Tadi, Peyman, Delfinis, Luca J., Schlattner, U., Simpson, Jeremy A., Hawke, Thomas J., Perry, Christopher G.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596403/
https://www.ncbi.nlm.nih.gov/pubmed/30938481
http://dx.doi.org/10.1002/jcsm.12405

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