Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

Microglia rapidly respond to changes in neural activity and inflammation to regulate synaptic connectivity. The extracellular signals, particularly neuron-derived molecules, that drive these microglial functions at synapses remains a key open question. Here, whisker lesioning, known to dampen cortic...

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Detalles Bibliográficos
Autores principales: Gunner, Georgia, Cheadle, Lucas, Johnson, Kasey M., Ayata, Pinar, Badimon, Ana, Mondo, Erica, Nagy, M. Aurel, Liu, Liwang, Bemiller, Shane M., Kim, Ki-Wook, Lira, Sergio A., Lamb, Bruce T., Tapper, Andrew R., Ransohoff, Richard M., Greenberg, Michael E., Schaefer, Anne, Schafer, Dorothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596419/
https://www.ncbi.nlm.nih.gov/pubmed/31209379
http://dx.doi.org/10.1038/s41593-019-0419-y

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