PAVOOC: designing CRISPR sgRNAs using 3D protein structures and functional domain annotations

SUMMARY: Single-guide RNAs (sgRNAs) targeting the same gene can significantly vary in terms of efficacy and specificity. PAVOOC (Prediction And Visualization of On- and Off-targets for CRISPR) is a web-based CRISPR sgRNA design tool that employs state of the art machine learning models to prioritize...

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Detalles Bibliográficos
Autores principales: Schaefer, Moritz, Clevert, Djork-Arné, Weiss, Bertram, Steffen, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596878/
https://www.ncbi.nlm.nih.gov/pubmed/30445568
http://dx.doi.org/10.1093/bioinformatics/bty935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596878/
https://www.ncbi.nlm.nih.gov/pubmed/30445568
http://dx.doi.org/10.1093/bioinformatics/bty935

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