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PAVOOC: designing CRISPR sgRNAs using 3D protein structures and functional domain annotations
SUMMARY: Single-guide RNAs (sgRNAs) targeting the same gene can significantly vary in terms of efficacy and specificity. PAVOOC (Prediction And Visualization of On- and Off-targets for CRISPR) is a web-based CRISPR sgRNA design tool that employs state of the art machine learning models to prioritize...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596878/ https://www.ncbi.nlm.nih.gov/pubmed/30445568 http://dx.doi.org/10.1093/bioinformatics/bty935 |