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Cohort study on the effects of depression on atherosclerotic cardiovascular disease risk in Korea
OBJECTIVES: Depression has been reported to be a risk factor of cardiovascular disease in the western world, but the association has not yet been studied among Asian populations. The aim of this study was to investigate whether depression increases the risk of developing atherosclerotic cardiovascul...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596942/ https://www.ncbi.nlm.nih.gov/pubmed/31227532 http://dx.doi.org/10.1136/bmjopen-2018-026913 |
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author | Jee, Yon Ho Chang, Hyoungyoon Jung, Keum Ji Jee, Sun Ha |
author_facet | Jee, Yon Ho Chang, Hyoungyoon Jung, Keum Ji Jee, Sun Ha |
author_sort | Jee, Yon Ho |
collection | PubMed |
description | OBJECTIVES: Depression has been reported to be a risk factor of cardiovascular disease in the western world, but the association has not yet been studied among Asian populations. The aim of this study was to investigate whether depression increases the risk of developing atherosclerotic cardiovascular disease (ASCVD) in a large Korean cohort study. DESIGN: Population based cohort study. SETTING: Database of National Health Insurance System, Republic of Korea. PARTICIPANTS: 481 355 Koreans (260 695 men and 220 660 women) aged 40–80 years who had a biennial health check-up between 2002 and 2005. MAIN OUTCOME MEASURE: The main outcome in this study was the first ASCVD event (hospital admission or death). RESULTS: Depression increased the risk of developing ASCVD by 41% for men and 48% for women. In men, 3–4 outpatient visits for depression increased the risk of angina pectoris by 2.12 times (95% CI 1.55 to 2.90) and acute myocardial infarction by 2.29 times (95% CI 1.33 to 3.95). Depression was also associated with stroke in men (HR 1.29, 95% CI 1.19 to 1.39) and in women (HR 1.37, 95% CI 1.29 to 1.46). However, no increased risk of ASCVD was found for men who received 10 or more depressive treatments, compared with those without any outpatient visit for depression. CONCLUSIONS: In this cohort, depressed people were at increased risk of ASCVD incidence. Therefore, individuals with depression may need routine monitoring of heart health that may prevent their future CVD risk. |
format | Online Article Text |
id | pubmed-6596942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-65969422019-07-18 Cohort study on the effects of depression on atherosclerotic cardiovascular disease risk in Korea Jee, Yon Ho Chang, Hyoungyoon Jung, Keum Ji Jee, Sun Ha BMJ Open Public Health OBJECTIVES: Depression has been reported to be a risk factor of cardiovascular disease in the western world, but the association has not yet been studied among Asian populations. The aim of this study was to investigate whether depression increases the risk of developing atherosclerotic cardiovascular disease (ASCVD) in a large Korean cohort study. DESIGN: Population based cohort study. SETTING: Database of National Health Insurance System, Republic of Korea. PARTICIPANTS: 481 355 Koreans (260 695 men and 220 660 women) aged 40–80 years who had a biennial health check-up between 2002 and 2005. MAIN OUTCOME MEASURE: The main outcome in this study was the first ASCVD event (hospital admission or death). RESULTS: Depression increased the risk of developing ASCVD by 41% for men and 48% for women. In men, 3–4 outpatient visits for depression increased the risk of angina pectoris by 2.12 times (95% CI 1.55 to 2.90) and acute myocardial infarction by 2.29 times (95% CI 1.33 to 3.95). Depression was also associated with stroke in men (HR 1.29, 95% CI 1.19 to 1.39) and in women (HR 1.37, 95% CI 1.29 to 1.46). However, no increased risk of ASCVD was found for men who received 10 or more depressive treatments, compared with those without any outpatient visit for depression. CONCLUSIONS: In this cohort, depressed people were at increased risk of ASCVD incidence. Therefore, individuals with depression may need routine monitoring of heart health that may prevent their future CVD risk. BMJ Publishing Group 2019-06-20 /pmc/articles/PMC6596942/ /pubmed/31227532 http://dx.doi.org/10.1136/bmjopen-2018-026913 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Public Health Jee, Yon Ho Chang, Hyoungyoon Jung, Keum Ji Jee, Sun Ha Cohort study on the effects of depression on atherosclerotic cardiovascular disease risk in Korea |
title | Cohort study on the effects of depression on atherosclerotic cardiovascular disease risk in Korea |
title_full | Cohort study on the effects of depression on atherosclerotic cardiovascular disease risk in Korea |
title_fullStr | Cohort study on the effects of depression on atherosclerotic cardiovascular disease risk in Korea |
title_full_unstemmed | Cohort study on the effects of depression on atherosclerotic cardiovascular disease risk in Korea |
title_short | Cohort study on the effects of depression on atherosclerotic cardiovascular disease risk in Korea |
title_sort | cohort study on the effects of depression on atherosclerotic cardiovascular disease risk in korea |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596942/ https://www.ncbi.nlm.nih.gov/pubmed/31227532 http://dx.doi.org/10.1136/bmjopen-2018-026913 |
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