Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates

Peptide immunogens provide an approach to focus antibody responses to specific neutralizing sites on the HIV envelope protein (Env) trimer or on other pathogens. However, the physical characteristics of peptide immunogens can limit their pharmacokinetic and immunological properties. Here, we have de...

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Detalles Bibliográficos
Autores principales: Francica, Joseph R., Laga, Richard, Lynn, Geoffrey M., Mužíková, Gabriela, Androvič, Ladislav, Aussedat, Baptiste, Walkowicz, William E., Padhan, Kartika, Ramirez-Valdez, Ramiro Andrei, Parks, Robert, Schmidt, Stephen D., Flynn, Barbara J., Tsybovsky, Yaroslav, Stewart-Jones, Guillaume B. E., Saunders, Kevin O., Baharom, Faezzah, Petrovas, Constantinos, Haynes, Barton F., Seder, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597128/
https://www.ncbi.nlm.nih.gov/pubmed/31206510
http://dx.doi.org/10.1371/journal.pbio.3000328

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