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Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

In bladder, loss of mammalian Sonic Hedgehog (Shh) accompanies progression to invasive urothelial carcinoma, but the molecular mechanisms underlying this cancer-initiating event are poorly defined. Here, we show that loss of Shh results from hypermethylation of the CpG shore of the Shh gene, and tha...

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Detalles Bibliográficos
Autores principales:	Kim, SungEun, Kim, Yubin, Kong, JungHo, Kim, Eunjee, Choi, Jae Hyeok, Yuk, Hyeong Dong, Lee, HyeSun, Kim, Hwa-Ryeon, Lee, Kyoung-Hwa, Kang, Minyong, Roe, Jae-Seok, Moon, Kyung Chul, Kim, Sanguk, Ku, Ja Hyeon, Shin, Kunyoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597241/ https://www.ncbi.nlm.nih.gov/pubmed/31036156 http://dx.doi.org/10.7554/eLife.43024

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