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The Role of Ca(V)2.1 Channel Facilitation in Synaptic Facilitation

Activation of Ca(V)2.1 voltage-gated calcium channels is facilitated by preceding calcium entry. Such self-modulatory facilitation is thought to contribute to synaptic facilitation. Using knockin mice with mutated Ca(V)2.1 channels that do not facilitate (Ca IM-AA mice), we surprisingly found that,...

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Detalles Bibliográficos
Autores principales:	Weyrer, Christopher, Turecek, Josef, Niday, Zachary, Liu, Pin W., Nanou, Evanthia, Catterall, William A., Bean, Bruce P., Regehr, Wade G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597251/ https://www.ncbi.nlm.nih.gov/pubmed/30811980 http://dx.doi.org/10.1016/j.celrep.2019.01.114

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