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Central nervous system regeneration is driven by microglia necroptosis and repopulation
Failed regeneration of central nervous system myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here, we reveal that efficient remyelination requires death of pro-inflammatory microglia followed by repopulation t...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597360/ https://www.ncbi.nlm.nih.gov/pubmed/31182869 http://dx.doi.org/10.1038/s41593-019-0418-z |
| _version_ | 1783430571013177344 |
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| author | Lloyd, Amy F. Davies, Claire L. Holloway, Rebecca K. Labrak, Yasmine Ireland, Graeme Carradori, Dario Dillenburg, Alessandra Borger, Eva Soong, Daniel Richardson, Jill C. Kuhlmann, Tanja Williams, Anna Pollard, Jeffrey W. des Rieux, Anne Priller, Josef Miron, Veronique E. |
| author_facet | Lloyd, Amy F. Davies, Claire L. Holloway, Rebecca K. Labrak, Yasmine Ireland, Graeme Carradori, Dario Dillenburg, Alessandra Borger, Eva Soong, Daniel Richardson, Jill C. Kuhlmann, Tanja Williams, Anna Pollard, Jeffrey W. des Rieux, Anne Priller, Josef Miron, Veronique E. |
| author_sort | Lloyd, Amy F. |
| collection | PubMed |
| description | Failed regeneration of central nervous system myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here, we reveal that efficient remyelination requires death of pro-inflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and reveal novel therapeutic targets to promote white matter regeneration. |
| format | Online Article Text |
| id | pubmed-6597360 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-65973602019-12-10 Central nervous system regeneration is driven by microglia necroptosis and repopulation Lloyd, Amy F. Davies, Claire L. Holloway, Rebecca K. Labrak, Yasmine Ireland, Graeme Carradori, Dario Dillenburg, Alessandra Borger, Eva Soong, Daniel Richardson, Jill C. Kuhlmann, Tanja Williams, Anna Pollard, Jeffrey W. des Rieux, Anne Priller, Josef Miron, Veronique E. Nat Neurosci Article Failed regeneration of central nervous system myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here, we reveal that efficient remyelination requires death of pro-inflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and reveal novel therapeutic targets to promote white matter regeneration. 2019-06-05 2019-06-10 /pmc/articles/PMC6597360/ /pubmed/31182869 http://dx.doi.org/10.1038/s41593-019-0418-z Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Lloyd, Amy F. Davies, Claire L. Holloway, Rebecca K. Labrak, Yasmine Ireland, Graeme Carradori, Dario Dillenburg, Alessandra Borger, Eva Soong, Daniel Richardson, Jill C. Kuhlmann, Tanja Williams, Anna Pollard, Jeffrey W. des Rieux, Anne Priller, Josef Miron, Veronique E. Central nervous system regeneration is driven by microglia necroptosis and repopulation |
| title | Central nervous system regeneration is driven by microglia
necroptosis and repopulation |
| title_full | Central nervous system regeneration is driven by microglia
necroptosis and repopulation |
| title_fullStr | Central nervous system regeneration is driven by microglia
necroptosis and repopulation |
| title_full_unstemmed | Central nervous system regeneration is driven by microglia
necroptosis and repopulation |
| title_short | Central nervous system regeneration is driven by microglia
necroptosis and repopulation |
| title_sort | central nervous system regeneration is driven by microglia
necroptosis and repopulation |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597360/ https://www.ncbi.nlm.nih.gov/pubmed/31182869 http://dx.doi.org/10.1038/s41593-019-0418-z |
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