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Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection

BACKGROUND: Recurrent respiratory tract infection (RRTI) is a disease occurred frequently in preschool children. METHODS: A total of 120 RRTI children were randomly divided into active group, remission group, intervention group and control group, meanwhile 30 healthy children were selected as the he...

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Autores principales: Li, Ke-Liang, Wang, Ben-Zhen, Li, Zi-Pu, Li, Yi-Lei, Liang, Jing-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597592/
https://www.ncbi.nlm.nih.gov/pubmed/31020541
http://dx.doi.org/10.1007/s12519-019-00248-0
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author Li, Ke-Liang
Wang, Ben-Zhen
Li, Zi-Pu
Li, Yi-Lei
Liang, Jing-Jing
author_facet Li, Ke-Liang
Wang, Ben-Zhen
Li, Zi-Pu
Li, Yi-Lei
Liang, Jing-Jing
author_sort Li, Ke-Liang
collection PubMed
description BACKGROUND: Recurrent respiratory tract infection (RRTI) is a disease occurred frequently in preschool children. METHODS: A total of 120 RRTI children were randomly divided into active group, remission group, intervention group and control group, meanwhile 30 healthy children were selected as the healthy group. Children in the intervention group were given oral Bifidobaeterium tetravaccine tablets (Live) for 2 months, while the control group received routine treatment. Stool sample were detected to analyze the bacterial strains. The occurrence of respiratory tract infection (RTI) was compared between different groups during 1 year follow-up. RESULTS: Compared with the healthy group, the number of Bifidobacteria and Lactobacilli in the active group, remission group, intervention group and control group was significantly decreased (P < 0.05). The number of Bifidobacteria and Lactobacilli in the intervention group was significantly higher compared to other RRTI groups (P < 0.05). During the follow-up period, the average annual frequency of different acute RTI and use of antibiotics were significantly reduced (P < 0.05), the average duration of cough, fever and use of antibiotics at each episode were also significantly shortened (P < 0.05) in the intervention group compared to the control group. CONCLUSIONS: Children with RRTI are susceptible to intestinal flora imbalance. Oral probiotics can effectively improve the RRTI intestinal microecological balance in children and reduce the frequency of RTI.
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spelling pubmed-65975922019-07-18 Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection Li, Ke-Liang Wang, Ben-Zhen Li, Zi-Pu Li, Yi-Lei Liang, Jing-Jing World J Pediatr Original Article BACKGROUND: Recurrent respiratory tract infection (RRTI) is a disease occurred frequently in preschool children. METHODS: A total of 120 RRTI children were randomly divided into active group, remission group, intervention group and control group, meanwhile 30 healthy children were selected as the healthy group. Children in the intervention group were given oral Bifidobaeterium tetravaccine tablets (Live) for 2 months, while the control group received routine treatment. Stool sample were detected to analyze the bacterial strains. The occurrence of respiratory tract infection (RTI) was compared between different groups during 1 year follow-up. RESULTS: Compared with the healthy group, the number of Bifidobacteria and Lactobacilli in the active group, remission group, intervention group and control group was significantly decreased (P < 0.05). The number of Bifidobacteria and Lactobacilli in the intervention group was significantly higher compared to other RRTI groups (P < 0.05). During the follow-up period, the average annual frequency of different acute RTI and use of antibiotics were significantly reduced (P < 0.05), the average duration of cough, fever and use of antibiotics at each episode were also significantly shortened (P < 0.05) in the intervention group compared to the control group. CONCLUSIONS: Children with RRTI are susceptible to intestinal flora imbalance. Oral probiotics can effectively improve the RRTI intestinal microecological balance in children and reduce the frequency of RTI. Springer Singapore 2019-04-24 2019 /pmc/articles/PMC6597592/ /pubmed/31020541 http://dx.doi.org/10.1007/s12519-019-00248-0 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Li, Ke-Liang
Wang, Ben-Zhen
Li, Zi-Pu
Li, Yi-Lei
Liang, Jing-Jing
Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection
title Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection
title_full Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection
title_fullStr Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection
title_full_unstemmed Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection
title_short Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection
title_sort alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597592/
https://www.ncbi.nlm.nih.gov/pubmed/31020541
http://dx.doi.org/10.1007/s12519-019-00248-0
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