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Animal Study to Evaluate the Effect of Carbon Dioxide Insufflation on Recurrent Laryngeal Nerve Function in Transoral Endoscopic Thyroidectomy

Data with regard to potential recurrent laryngeal nerve (RLN) compromise caused by intra-neck CO(2) insufflation during transoral endoscopic thyroidectomy vestibular approach (TOETVA) are missing. RLN electromyographic (EMG) profiles, metabolic and hemodynamic parameters (oxygen saturation, heart ra...

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Autores principales: Zhang, Daqi, Li, Shijie, Dionigi, Gianlorenzo, Zhang, Jiao, Niu, Chunbo, Wang, Tie, Liang, Nan, Sun, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597721/
https://www.ncbi.nlm.nih.gov/pubmed/31249351
http://dx.doi.org/10.1038/s41598-019-45779-8
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author Zhang, Daqi
Li, Shijie
Dionigi, Gianlorenzo
Zhang, Jiao
Niu, Chunbo
Wang, Tie
Liang, Nan
Sun, Hui
author_facet Zhang, Daqi
Li, Shijie
Dionigi, Gianlorenzo
Zhang, Jiao
Niu, Chunbo
Wang, Tie
Liang, Nan
Sun, Hui
author_sort Zhang, Daqi
collection PubMed
description Data with regard to potential recurrent laryngeal nerve (RLN) compromise caused by intra-neck CO(2) insufflation during transoral endoscopic thyroidectomy vestibular approach (TOETVA) are missing. RLN electromyographic (EMG) profiles, metabolic and hemodynamic parameters (oxygen saturation, heart rate, blood pressure, experimental time, CO(2) partial pressure, pH, O(2) partial pressure), central venous pressure (CVP), airpocket temperature and pressure were recorded in a TOETVA animal model. Twelve pigs were randomly divided into different groups according to increasing CO(2) insufflation pressures. Nerves segments were then collected for histopathology. Significant variation of metabolic and hemodynamic parameters were registered when CO(2) insufflation pressures increased x3 and x5 the baseline parameters. Combined EMG amplitude drop and latency increase also were documented. There was no significant change in the intraluminal temperature. RLNs structure were preserved with normal axons, no fibrosis, and no vacuolization and without loss of myelinated fibers during the experiment. RLN EMG profiles (but not histology) were altered when CO(2) insufflation pressures increased.
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spelling pubmed-65977212019-07-09 Animal Study to Evaluate the Effect of Carbon Dioxide Insufflation on Recurrent Laryngeal Nerve Function in Transoral Endoscopic Thyroidectomy Zhang, Daqi Li, Shijie Dionigi, Gianlorenzo Zhang, Jiao Niu, Chunbo Wang, Tie Liang, Nan Sun, Hui Sci Rep Article Data with regard to potential recurrent laryngeal nerve (RLN) compromise caused by intra-neck CO(2) insufflation during transoral endoscopic thyroidectomy vestibular approach (TOETVA) are missing. RLN electromyographic (EMG) profiles, metabolic and hemodynamic parameters (oxygen saturation, heart rate, blood pressure, experimental time, CO(2) partial pressure, pH, O(2) partial pressure), central venous pressure (CVP), airpocket temperature and pressure were recorded in a TOETVA animal model. Twelve pigs were randomly divided into different groups according to increasing CO(2) insufflation pressures. Nerves segments were then collected for histopathology. Significant variation of metabolic and hemodynamic parameters were registered when CO(2) insufflation pressures increased x3 and x5 the baseline parameters. Combined EMG amplitude drop and latency increase also were documented. There was no significant change in the intraluminal temperature. RLNs structure were preserved with normal axons, no fibrosis, and no vacuolization and without loss of myelinated fibers during the experiment. RLN EMG profiles (but not histology) were altered when CO(2) insufflation pressures increased. Nature Publishing Group UK 2019-06-27 /pmc/articles/PMC6597721/ /pubmed/31249351 http://dx.doi.org/10.1038/s41598-019-45779-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Daqi
Li, Shijie
Dionigi, Gianlorenzo
Zhang, Jiao
Niu, Chunbo
Wang, Tie
Liang, Nan
Sun, Hui
Animal Study to Evaluate the Effect of Carbon Dioxide Insufflation on Recurrent Laryngeal Nerve Function in Transoral Endoscopic Thyroidectomy
title Animal Study to Evaluate the Effect of Carbon Dioxide Insufflation on Recurrent Laryngeal Nerve Function in Transoral Endoscopic Thyroidectomy
title_full Animal Study to Evaluate the Effect of Carbon Dioxide Insufflation on Recurrent Laryngeal Nerve Function in Transoral Endoscopic Thyroidectomy
title_fullStr Animal Study to Evaluate the Effect of Carbon Dioxide Insufflation on Recurrent Laryngeal Nerve Function in Transoral Endoscopic Thyroidectomy
title_full_unstemmed Animal Study to Evaluate the Effect of Carbon Dioxide Insufflation on Recurrent Laryngeal Nerve Function in Transoral Endoscopic Thyroidectomy
title_short Animal Study to Evaluate the Effect of Carbon Dioxide Insufflation on Recurrent Laryngeal Nerve Function in Transoral Endoscopic Thyroidectomy
title_sort animal study to evaluate the effect of carbon dioxide insufflation on recurrent laryngeal nerve function in transoral endoscopic thyroidectomy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597721/
https://www.ncbi.nlm.nih.gov/pubmed/31249351
http://dx.doi.org/10.1038/s41598-019-45779-8
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