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Modulation of extrasynaptic GABA(A) alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner
Hippocampal hyperactivity is correlated with psychosis in schizophrenia patients and likely attributable to deficits in GABAergic signaling. Here we attempt to reverse this deficit by overexpression of the α5-GABA(A) receptor within the ventral hippocampus (vHipp). Indeed, this is sufficient to norm...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597724/ https://www.ncbi.nlm.nih.gov/pubmed/31249307 http://dx.doi.org/10.1038/s41467-019-10800-1 |