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Modulation of extrasynaptic GABA(A) alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner

Hippocampal hyperactivity is correlated with psychosis in schizophrenia patients and likely attributable to deficits in GABAergic signaling. Here we attempt to reverse this deficit by overexpression of the α5-GABA(A) receptor within the ventral hippocampus (vHipp). Indeed, this is sufficient to norm...

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Detalles Bibliográficos
Autores principales:	Donegan, J. J., Boley, A. M., Yamaguchi, J., Toney, G. M., Lodge, D. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597724/ https://www.ncbi.nlm.nih.gov/pubmed/31249307 http://dx.doi.org/10.1038/s41467-019-10800-1

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