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E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, and both genetic and histopathological evidence have implicated the ubiquitous presynaptic protein α-synuclein (αSyn) in its pathogenesis. Recent work has investigated how disrupting αSyn's interaction with mem...

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Detalles Bibliográficos
Autores principales:	Rovere, Matteo, Powers, Alex E., Jiang, Haiyang, Pitino, Julia C., Fonseca-Ornelas, Luis, Patel, Dushyant S., Achille, Alessandro, Langen, Ralf, Varkey, Jobin, Bartels, Tim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597829/ https://www.ncbi.nlm.nih.gov/pubmed/31048377 http://dx.doi.org/10.1074/jbc.RA118.006551

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