Pathogenic tau does not drive activation of the unfolded protein response

The unfolded protein response (UPR) is commonly associated with a range of neurodegenerative diseases, and targeting UPR components has been suggested as a therapeutic strategy. The UPR surveys protein folding within the endoplasmic reticulum. However, many of the misfolded proteins that accumulate...

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Detalles Bibliográficos
Autores principales: Pitera, Aleksandra P., Asuni, Ayodeji A., O'Connor, Vincent, Deinhardt, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Neurobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597832/
https://www.ncbi.nlm.nih.gov/pubmed/31053641
http://dx.doi.org/10.1074/jbc.RA119.008263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597832/
https://www.ncbi.nlm.nih.gov/pubmed/31053641
http://dx.doi.org/10.1074/jbc.RA119.008263

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