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Pathogenic tau does not drive activation of the unfolded protein response

The unfolded protein response (UPR) is commonly associated with a range of neurodegenerative diseases, and targeting UPR components has been suggested as a therapeutic strategy. The UPR surveys protein folding within the endoplasmic reticulum. However, many of the misfolded proteins that accumulate...

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Detalles Bibliográficos
Autores principales:	Pitera, Aleksandra P., Asuni, Ayodeji A., O'Connor, Vincent, Deinhardt, Katrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597832/ https://www.ncbi.nlm.nih.gov/pubmed/31053641 http://dx.doi.org/10.1074/jbc.RA119.008263

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