Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute

Hemoglobin (Hb)-based oxygen carriers (HBOC) are modified extracellular proteins, designed to replace or augment the oxygen-carrying capacity of erythrocytes. However, clinical results have generally been disappointing due to adverse side effects, in part linked to the intrinsic oxidative toxicity o...

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Detalles Bibliográficos
Autores principales: Cooper, Chris E., Silkstone, Gary G.A., Simons, Michelle, Rajagopal, Badri, Syrett, Natalie, Shaik, Thoufieq, Gretton, Svetlana, Welbourn, Elizabeth, Bülow, Leif, Eriksson, Nélida Leiva, Ronda, Luca, Mozzarelli, Andrea, Eke, Andras, Mathe, Domokos, Reeder, Brandon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597946/
https://www.ncbi.nlm.nih.gov/pubmed/30594736
http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.030

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