Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients

Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy...

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Autores principales: Griffiths, William J., Abdel-Khalik, Jonas, Yutuc, Eylan, Roman, Gustavo, Warner, Margaret, Gustafsson, Jan-Åke, Wang, Yuqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597949/
https://www.ncbi.nlm.nih.gov/pubmed/30578919
http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.020
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author Griffiths, William J.
Abdel-Khalik, Jonas
Yutuc, Eylan
Roman, Gustavo
Warner, Margaret
Gustafsson, Jan-Åke
Wang, Yuqin
author_facet Griffiths, William J.
Abdel-Khalik, Jonas
Yutuc, Eylan
Roman, Gustavo
Warner, Margaret
Gustafsson, Jan-Åke
Wang, Yuqin
author_sort Griffiths, William J.
collection PubMed
description Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups.
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spelling pubmed-65979492019-07-11 Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients Griffiths, William J. Abdel-Khalik, Jonas Yutuc, Eylan Roman, Gustavo Warner, Margaret Gustafsson, Jan-Åke Wang, Yuqin Free Radic Biol Med Article Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer's disease patient-group. This was the only sterol found to be changed amongst the different groups. Elsevier Science 2019-04 /pmc/articles/PMC6597949/ /pubmed/30578919 http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.020 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Griffiths, William J.
Abdel-Khalik, Jonas
Yutuc, Eylan
Roman, Gustavo
Warner, Margaret
Gustafsson, Jan-Åke
Wang, Yuqin
Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
title Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
title_full Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
title_fullStr Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
title_full_unstemmed Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
title_short Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
title_sort concentrations of bile acid precursors in cerebrospinal fluid of alzheimer's disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597949/
https://www.ncbi.nlm.nih.gov/pubmed/30578919
http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.020
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