Choroid Plexus Acts as Gatekeeper for TREM2, Abnormal Accumulation of ApoE, and Fibrillary Tau in Alzheimer’s Disease and in Down Syndrome Dementia

BACKGROUND: Genetic factors that influence Alzheimer’s disease (AD) risk include mutations in TREM2 and allelic variants of Apolipoprotein E, influencing AD pathology in the general population and in Down syndrome (DS). Evidence shows that dysfunction of the choroid plexus may compromise the blood-c...

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Autores principales: Raha-Chowdhury, Ruma, Henderson, James W., Raha, Animesh Alexander, Vuono, Romina, Bickerton, Anastasia, Jones, Elizabeth, Fincham, Robert, Allinson, Kieren, Holland, Anthony, Zaman, Shahid H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2019
Materias:
Researh Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598012/
https://www.ncbi.nlm.nih.gov/pubmed/30909239
http://dx.doi.org/10.3233/JAD-181179

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