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Protective role of Roflumilast against cadmium-induced cardiotoxicity through inhibition of oxidative stress and NF-κB signaling in rats

Cadmium (Cd), a potent cardiotoxic environmental heavy metal, induces oxidative stress and membrane disturbances in cardiac myocytes. Phosphodiesterase (PDEs) retards the positive inotropic effects of β-adrenoceptor activation by decreasing levels of cAMP via degradation. Hence, PDE inhibitors sensi...

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Detalles Bibliográficos
Autores principales:	Ansari, Mohd Nazam, Ganaie, Majid A., Rehman, Najeeb Ur, Alharthy, Khalid M., Khan, Tajdar H., Imam, Faisal, Ansari, Mushtaq A., Al-Harbi, Naif O., Jan, Basit L., Sheikh, Ishfaq A., Hamad, Abubaker M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598217/ https://www.ncbi.nlm.nih.gov/pubmed/31297022 http://dx.doi.org/10.1016/j.jsps.2019.04.002

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