Synthesis, anticancer, apoptosis-inducing activities and EGFR and VEGFR2 assay mechanistic studies of 5,5-diphenylimidazolidine-2,4-dione derivatives: Molecular docking studies

A new series of 5,5-diphenylhydantoin derivatives containing benzylidene or isatin (4–19) was synthesized. Their anticancer activity against HeLa, a cervical cancer cell line, A549, a lung cancer cell line, and MDA-MB-231, a breast cancer cell line, was evaluated. Compounds 13, 16, 17 and 18 exhibit...

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Detalles Bibliográficos
Autores principales: Alkahtani, Hamad M., Alanazi, Mohammed M., Aleanizy, Fadilah Sfouq, Alqahtani, Fulwah Yahya, Alhoshani, Ali, Alanazi, Fawaz E., Almehizia, Abdulrahman A., Abdalla, Ashraf N., Alanazi, Mashael G., El-Azab, Adel S., Abdel-Aziz, Alaa A.-M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598223/
https://www.ncbi.nlm.nih.gov/pubmed/31297023
http://dx.doi.org/10.1016/j.jsps.2019.04.003

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