Directly compressed rosuvastatin calcium tablets that offer hydrotropic and micellar solubilization for improved dissolution rate and extent of drug release

The objective was to use caffeine and Soluplus® to improve the dissolution rate and to maintain a concentration of BCS Class II rosuvastatin calcium that exceeds its solubility. Caffeine and Soluplus® together substantially improved the dissolution rate and the extent of rosuvastatin release. Formul...

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Detalles Bibliográficos
Autores principales: Butt, Sharonia, Hasan, Syed Muhammad Farid, Hassan, Muhammad Mohtasheemul, Alkharfy, Khalid M., Neau, Steven Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598454/
https://www.ncbi.nlm.nih.gov/pubmed/31297015
http://dx.doi.org/10.1016/j.jsps.2019.03.002

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