Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan

Reports indicate lower Down syndrome (DS) survival among females than among males in Australia, contrasting with female longevity in the general population. Using data on 1310 people with DS (626 females and 684 males) in Japan from five hospitals’ medical records and questionnaires completed by par...

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Detalles Bibliográficos
Autores principales: Takano, Takako, Akagi, Michio, Takaki, Haruyoshi, Inuzuka, Ryo, Nogimori, Yoshitsugu, Ono, Hiroshi, Kaneko, Masahide, Hagiwara, Norifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598551/
https://www.ncbi.nlm.nih.gov/pubmed/31321317
http://dx.doi.org/10.1136/bmjpo-2018-000414
Descripción
Sumario:Reports indicate lower Down syndrome (DS) survival among females than among males in Australia, contrasting with female longevity in the general population. Using data on 1310 people with DS (626 females and 684 males) in Japan from five hospitals’ medical records and questionnaires completed by parents of people with DS, we investigated sex differences in congenital heart disease (CHD), which may be related to mortality. The CHD rate was significantly higher for females (354, 57%) than for males (338, 49%; p=0.010). Significantly more females (199, 32%) than males (175, 26%) underwent surgery for CHD (p=0.018).

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