Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan

Reports indicate lower Down syndrome (DS) survival among females than among males in Australia, contrasting with female longevity in the general population. Using data on 1310 people with DS (626 females and 684 males) in Japan from five hospitals’ medical records and questionnaires completed by par...

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Autores principales: Takano, Takako, Akagi, Michio, Takaki, Haruyoshi, Inuzuka, Ryo, Nogimori, Yoshitsugu, Ono, Hiroshi, Kaneko, Masahide, Hagiwara, Norifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598551/
https://www.ncbi.nlm.nih.gov/pubmed/31321317
http://dx.doi.org/10.1136/bmjpo-2018-000414
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author Takano, Takako
Akagi, Michio
Takaki, Haruyoshi
Inuzuka, Ryo
Nogimori, Yoshitsugu
Ono, Hiroshi
Kaneko, Masahide
Hagiwara, Norifumi
author_facet Takano, Takako
Akagi, Michio
Takaki, Haruyoshi
Inuzuka, Ryo
Nogimori, Yoshitsugu
Ono, Hiroshi
Kaneko, Masahide
Hagiwara, Norifumi
author_sort Takano, Takako
collection PubMed
description Reports indicate lower Down syndrome (DS) survival among females than among males in Australia, contrasting with female longevity in the general population. Using data on 1310 people with DS (626 females and 684 males) in Japan from five hospitals’ medical records and questionnaires completed by parents of people with DS, we investigated sex differences in congenital heart disease (CHD), which may be related to mortality. The CHD rate was significantly higher for females (354, 57%) than for males (338, 49%; p=0.010). Significantly more females (199, 32%) than males (175, 26%) underwent surgery for CHD (p=0.018).
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spelling pubmed-65985512019-07-18 Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan Takano, Takako Akagi, Michio Takaki, Haruyoshi Inuzuka, Ryo Nogimori, Yoshitsugu Ono, Hiroshi Kaneko, Masahide Hagiwara, Norifumi BMJ Paediatr Open Research Letters Reports indicate lower Down syndrome (DS) survival among females than among males in Australia, contrasting with female longevity in the general population. Using data on 1310 people with DS (626 females and 684 males) in Japan from five hospitals’ medical records and questionnaires completed by parents of people with DS, we investigated sex differences in congenital heart disease (CHD), which may be related to mortality. The CHD rate was significantly higher for females (354, 57%) than for males (338, 49%; p=0.010). Significantly more females (199, 32%) than males (175, 26%) underwent surgery for CHD (p=0.018). BMJ Publishing Group 2019-06-26 /pmc/articles/PMC6598551/ /pubmed/31321317 http://dx.doi.org/10.1136/bmjpo-2018-000414 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research Letters
Takano, Takako
Akagi, Michio
Takaki, Haruyoshi
Inuzuka, Ryo
Nogimori, Yoshitsugu
Ono, Hiroshi
Kaneko, Masahide
Hagiwara, Norifumi
Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan
title Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan
title_full Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan
title_fullStr Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan
title_full_unstemmed Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan
title_short Sex differences in congenital heart disease in Down syndrome: study data from medical records and questionnaires in a region of Japan
title_sort sex differences in congenital heart disease in down syndrome: study data from medical records and questionnaires in a region of japan
topic Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598551/
https://www.ncbi.nlm.nih.gov/pubmed/31321317
http://dx.doi.org/10.1136/bmjpo-2018-000414
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