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Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries
BACKGROUND: Evidence on associations between occupational diesel exhaust and gasoline exposure and colorectal cancer is limited. We aimed to assess the effect of workplace exposure to diesel exhaust and gasoline on the risk of colorectal cancer. METHODS: This case–control study included 181,709 colo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Occupational Safety and Health Research Institute
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598825/ https://www.ncbi.nlm.nih.gov/pubmed/31297276 http://dx.doi.org/10.1016/j.shaw.2019.01.001 |
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author | Talibov, Madar Sormunen, Jorma Weiderpass, Elisabete Kjaerheim, Kristina Martinsen, Jan-Ivar Sparen, Per Tryggvadottir, Laufey Hansen, Johnni Pukkala, Eero |
author_facet | Talibov, Madar Sormunen, Jorma Weiderpass, Elisabete Kjaerheim, Kristina Martinsen, Jan-Ivar Sparen, Per Tryggvadottir, Laufey Hansen, Johnni Pukkala, Eero |
author_sort | Talibov, Madar |
collection | PubMed |
description | BACKGROUND: Evidence on associations between occupational diesel exhaust and gasoline exposure and colorectal cancer is limited. We aimed to assess the effect of workplace exposure to diesel exhaust and gasoline on the risk of colorectal cancer. METHODS: This case–control study included 181,709 colon cancer and 109,227 rectal cancer cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden. Cases and controls were identified from the Nordic Occupational Cancer Study cohort and matched for country, birth year, and sex. Diesel exhaust and gasoline exposure values were assigned by country-specific job-exposure matrices. Odds ratios and 95% confidence intervals were calculated by using conditional logistic regression models. The results were adjusted for physical strain at work and occupational exposure to benzene, formaldehyde, ionizing radiation, chlorinated hydrocarbons, chromium, and wood dust. RESULTS: Diesel exhaust exposure was associated with a small increase in the risk of rectal cancer (odds ratio = 1.05, 95% confidence interval 1.02-1.08). Gasoline exposure was not associated with colorectal cancer risk. CONCLUSION: This study showed a small risk increase for rectal cancer after workplace diesel exhaust exposure. However, this finding could be due to chance, given the limitations of the study. |
format | Online Article Text |
id | pubmed-6598825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Occupational Safety and Health Research Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-65988252019-07-11 Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries Talibov, Madar Sormunen, Jorma Weiderpass, Elisabete Kjaerheim, Kristina Martinsen, Jan-Ivar Sparen, Per Tryggvadottir, Laufey Hansen, Johnni Pukkala, Eero Saf Health Work Original Article BACKGROUND: Evidence on associations between occupational diesel exhaust and gasoline exposure and colorectal cancer is limited. We aimed to assess the effect of workplace exposure to diesel exhaust and gasoline on the risk of colorectal cancer. METHODS: This case–control study included 181,709 colon cancer and 109,227 rectal cancer cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden. Cases and controls were identified from the Nordic Occupational Cancer Study cohort and matched for country, birth year, and sex. Diesel exhaust and gasoline exposure values were assigned by country-specific job-exposure matrices. Odds ratios and 95% confidence intervals were calculated by using conditional logistic regression models. The results were adjusted for physical strain at work and occupational exposure to benzene, formaldehyde, ionizing radiation, chlorinated hydrocarbons, chromium, and wood dust. RESULTS: Diesel exhaust exposure was associated with a small increase in the risk of rectal cancer (odds ratio = 1.05, 95% confidence interval 1.02-1.08). Gasoline exposure was not associated with colorectal cancer risk. CONCLUSION: This study showed a small risk increase for rectal cancer after workplace diesel exhaust exposure. However, this finding could be due to chance, given the limitations of the study. Occupational Safety and Health Research Institute 2019-06 2019-01-09 /pmc/articles/PMC6598825/ /pubmed/31297276 http://dx.doi.org/10.1016/j.shaw.2019.01.001 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Talibov, Madar Sormunen, Jorma Weiderpass, Elisabete Kjaerheim, Kristina Martinsen, Jan-Ivar Sparen, Per Tryggvadottir, Laufey Hansen, Johnni Pukkala, Eero Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries |
title | Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries |
title_full | Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries |
title_fullStr | Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries |
title_full_unstemmed | Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries |
title_short | Workplace Diesel Exhausts and Gasoline Exposure and Risk of Colorectal Cancer in Four Nordic Countries |
title_sort | workplace diesel exhausts and gasoline exposure and risk of colorectal cancer in four nordic countries |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598825/ https://www.ncbi.nlm.nih.gov/pubmed/31297276 http://dx.doi.org/10.1016/j.shaw.2019.01.001 |
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