Calcium activated nucleotidase 1 (CANT1) is critical for glycosaminoglycan biosynthesis in cartilage and endochondral ossification

Desbuquois dysplasia type 1 (DBQD1) is a chondrodysplasia caused by mutations in CANT1 gene encoding an ER/Golgi calcium activated nucleotidase 1 that hydrolyses UDP. Here, using Cant1 knock-in and knock-out mice recapitulating DBQD1 phenotype, we report that CANT1 plays a crucial role in cartilage...

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Detalles Bibliográficos
Autores principales: Paganini, Chiara, Monti, Luca, Costantini, Rossella, Besio, Roberta, Lecci, Silvia, Biggiogera, Marco, Tian, Kun, Schwartz, Jean-Marc, Huber, Céline, Cormier-Daire, Valérie, Gibson, Beth G., Pirog, Katarzyna A., Forlino, Antonella, Rossi, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598859/
https://www.ncbi.nlm.nih.gov/pubmed/30439444
http://dx.doi.org/10.1016/j.matbio.2018.11.002

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