Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies

PURPOSE: Immunogenicity against biotherapeutics can lead to the formation of drug/anti-drug-antibody (ADA) immune complexes (ICs) with potential impact on safety and drug pharmacokinetics (PK). This work aimed to generate defined drug/ADA ICs, characterized by quantitative (bio) analytical methods f...

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Detalles Bibliográficos
Autores principales: Hoffmann, Eugenia, Jordan, Gregor, Lauer, Matthias, Ringler, Philippe, Kusznir, Eric A., Rufer, Arne C., Huber, Sylwia, Jochner, Anton, Winter, Gerhard, Staack, Roland F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598957/
https://www.ncbi.nlm.nih.gov/pubmed/31254106
http://dx.doi.org/10.1007/s11095-019-2661-0

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