Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer

Lacking targetable molecular drivers, triple-negative breast cancer (TNBC) is the most clinically challenging subtype of breast cancer. In this study, we reveal that Death Effector Domain-containing DNA-binding protein (DEDD), which is overexpressed in > 60% of TNBCs, drives a mitogen-independent...

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Detalles Bibliográficos
Autores principales: Ni, Yingjia, Schmidt, Keon R., Werner, Barnes A., Koenig, Jenna K., Guldner, Ian H., Schnepp, Patricia M., Tan, Xuejuan, Jiang, Lan, Host, Misha, Sun, Longhua, Howe, Erin N., Wu, Junmin, Littlepage, Laurie E., Nakshatri, Harikrishna, Zhang, Siyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599020/
https://www.ncbi.nlm.nih.gov/pubmed/31253784
http://dx.doi.org/10.1038/s41467-019-10743-7

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