Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking

The sinus node is a collection of highly specialised cells constituting the heart’s pacemaker. The molecular underpinnings of its pacemaking abilities are debated. Using high-resolution mass spectrometry, we here quantify >7,000 proteins from sinus node and neighbouring atrial muscle. Abundances...

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Detalles Bibliográficos
Autores principales: Linscheid, Nora, Logantha, Sunil Jit R. J., Poulsen, Pi Camilla, Zhang, Shanzhuo, Schrölkamp, Maren, Egerod, Kristoffer Lihme, Thompson, Jonatan James, Kitmitto, Ashraf, Galli, Gina, Humphries, Martin J., Zhang, Henggui, Pers, Tune H., Olsen, Jesper Velgaard, Boyett, Mark, Lundby, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599035/
https://www.ncbi.nlm.nih.gov/pubmed/31253831
http://dx.doi.org/10.1038/s41467-019-10709-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599035/
https://www.ncbi.nlm.nih.gov/pubmed/31253831
http://dx.doi.org/10.1038/s41467-019-10709-9

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